Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde Foshan), Foshan 528308, China.
Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Nucleic Acids Res. 2021 Jan 8;49(D1):D65-D70. doi: 10.1093/nar/gkaa791.
RNA endowed with both protein-coding and noncoding functions is referred to as 'dual-function RNA', 'binary functional RNA (bifunctional RNA)' or 'cncRNA (coding and noncoding RNA)'. Recently, an increasing number of cncRNAs have been identified, including both translated ncRNAs (ncRNAs with coding functions) and untranslated mRNAs (mRNAs with noncoding functions). However, an appropriate database for storing and organizing cncRNAs is still lacking. Here, we developed cncRNAdb, a manually curated database of experimentally supported cncRNAs, which aims to provide a resource for efficient manipulation, browsing and analysis of cncRNAs. The current version of cncRNAdb documents about 2600 manually curated entries of cncRNA functions with experimental evidence, involving more than 2,000 RNAs (including over 1300 translated ncRNAs and over 600 untranslated mRNAs) across over 20 species. In summary, we believe that cncRNAdb will help elucidate the functions and mechanisms of cncRNAs and develop new prediction methods. The database is available at http://www.rna-society.org/cncrnadb/.
具有蛋白质编码和非编码功能的 RNA 被称为“双功能 RNA”、“双功能 RNA（bifunctional RNA）”或“cncRNA（编码和非编码 RNA）”。最近，越来越多的 cncRNA 被鉴定出来，包括具有编码功能的翻译 ncRNA（ncRNA）和具有非编码功能的未翻译的 mRNA（mRNA）。然而，仍然缺乏一个合适的数据库来存储和组织 cncRNA。在这里，我们开发了 cncRNAdb，这是一个经过人工整理的实验支持的 cncRNA 数据库，旨在为 cncRNA 的高效操作、浏览和分析提供资源。cncRNAdb 的当前版本记录了约 2600 个经过实验证据证实的 cncRNA 功能的人工整理条目，涉及 20 多个物种的 2000 多个 RNA（包括 1300 多个翻译 ncRNA 和 600 多个未翻译的 mRNA）。总之，我们相信 cncRNAdb 将有助于阐明 cncRNA 的功能和机制，并开发新的预测方法。该数据库可在 http://www.rna-society.org/cncrnadb/ 上获得。
