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医院急诊科真菌学表面污染与血液中NKT CD3(+) 16(+) 56(+)呈正相关，与其工作人员的CD4(+)细胞水平呈负相关。

Pollution of mycological surfaces in hospital emergency departments correlates positively with blood NKT CD3(+) 16(+) 56(+) and negatively with CD4(+) cell levels of their staff.

作者信息

Suska Milena, Lewicki Sławomir, Kiepura Anna, Winnicka Izabela, Leszczyński Paweł, Bielawska-Drózd Agata, Cieślik Piotr, Kubiak Leszek, Depczyńska Daria, Brewczyńska Aleksandra, Skopińska-Różewska Ewa, Kocik Janusz

机构信息

Department of Regenerative Medicine, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.

Laboratory of Epidemiology, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.

出版信息

Cent Eur J Immunol. 2016;41(1):71-7. doi: 10.5114/ceji.2016.58818. Epub 2016 Mar 24.

DOI:10.5114/ceji.2016.58818
PMID:27095925
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4829823/
Abstract

The aim of the present study was the assessment of the putative influence of yeast and filamentous fungi in healthcare and control (office) workplaces (10 of each kind) on immune system competence measured by NK (natural killer), CD4(+), and NKT (natural killer T lymphocyte) cell levels in the blood of the personnel employed at these workplaces. Imprints from floors and walls were collected in winter. The blood was taken in spring the following year, from 40 men, 26 to 53 years old, healthcare workers of hospital emergency departments (HED), who had been working for at least five years in their current positions, and from 36 corresponding controls, working in control offices. Evaluation of blood leukocyte subpopulations was done by flow cytometry. The qualitative analysis of the surface samples revealed a prevalence of strains belonging to Aspergillus spp. and Penicillium spp. genus. There was no statistically significant difference between the level of NKT; however, the percentage of NK cells was lower in the blood of HED workers than in the blood of offices personnel. Spearman analysis revealed the existence of positive correlation (r = 0.4677, p = 0.002) between the total CFU/25 cm(2) obtained by imprinting method from walls and floors of HED and the percentage of NKT (CD3(+)16(+)56(+)) lymphocytes collected from the blood of their personnel, and negative correlation (r = -0. 3688, p = 0.019) between this parameter of fungal pollution and the percentage of CD4(+) lymphocytes in the blood of HED staff. No other correlations were found.

摘要

本研究的目的是评估医疗保健场所和对照（办公室）工作场所（每种各10个）中的酵母和丝状真菌对免疫系统能力的假定影响，免疫系统能力通过这些工作场所员工血液中的自然杀伤（NK）细胞、CD4(+)细胞和自然杀伤T淋巴细胞（NKT）水平来衡量。冬季采集了地板和墙壁的印记样本。次年春季采集血液样本，样本来自40名年龄在26至53岁之间、在医院急诊科（HED）工作且至少在当前岗位工作五年的医护人员，以及36名在对照办公室工作的相应对照人员。通过流式细胞术对血液白细胞亚群进行评估。对表面样本的定性分析显示，属于曲霉属和青霉属的菌株占优势。NKT细胞水平之间没有统计学上的显著差异；然而，HED工作人员血液中的NK细胞百分比低于办公室人员血液中的NK细胞百分比。Spearman分析显示，通过印记法从HED的墙壁和地板获得的每25平方厘米总菌落形成单位（CFU）与从其工作人员血液中采集的NKT（CD3(+)16(+)56(+)）淋巴细胞百分比之间存在正相关（r = 0.4677，p = 0.002），并且该真菌污染参数与HED工作人员血液中CD4(+)淋巴细胞百分比之间存在负相关（r = -0.3688，p = 0.019）。未发现其他相关性。

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本文引用的文献

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Cent Eur J Immunol. 2015;40(3):360-5. doi: 10.5114/ceji.2015.54600. Epub 2015 Oct 15.
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Sclerotiorin is non-mutagenic and inhibits human PMNL 5-lipoxygenase and platelet aggregation.
核盘菌素无致突变性，可抑制人中性粒细胞5-脂氧合酶及血小板聚集。
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LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity.LAMP1/CD107a 对于有效地将穿孔素递送至溶酶体颗粒和 NK 细胞细胞毒性是必需的。
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