Goodwin Nicola, Karp Natasha A, Blackledge Samuel, Clark Bradley, Keeble Rosemary, Kovacs Ceri, Murray Katrina N, Price Michael, Thompson Peter, Bussell James
1 Research Support Facility, Wellcome Trust Sanger Institute , Cambridge, United Kingdom .
2 Department of Medicine, Laboratory of Molecular Biology, Cambridge University , Cambridge, United Kingdom .
Zebrafish. 2016 Jul;13 Suppl 1(Suppl 1):S164-8. doi: 10.1089/zeb.2016.1248. Epub 2016 Apr 20.
Managing the welfare of laboratory animals is critical to animal health, vital in the understanding of phenotypes created by treatment or genetic alteration and ensures compliance of regulations. Part of an animal welfare assessment is the requirement to record observations, ensuring all those responsible for the animals are aware of their health status and can act accordingly. Although the use of zebrafish in research continues to increase, guidelines for conducting welfare assessments and the reporting of observations are considered unclear compared to mammalian species. To support the movement of zebrafish between facilities, significant improvement would be achieved through the use of standardized terms to ensure clarity and consistency between facilities. Improving the clarity of terminology around welfare not only addresses our ethical obligation but also supports the research goals and provides a searchable description of the phenotypes. A Collaboration between the Wellcome Trust Sanger Institute and Cambridge University (Department of Medicine-Laboratory of Molecular Biology) has led to the creation of the zebrafish welfare terms from which standardization of terminology can be achieved.
管理实验动物的福利对于动物健康至关重要，对于理解由治疗或基因改变产生的表型至关重要，并确保法规的遵守。动物福利评估的一部分要求记录观察结果，以确保所有负责动物的人员了解它们的健康状况并能据此采取行动。尽管斑马鱼在研究中的使用持续增加，但与哺乳动物相比，进行福利评估和报告观察结果的指南仍被认为不够清晰。为了支持斑马鱼在不同设施之间的转移，通过使用标准化术语以确保各设施之间的清晰度和一致性，将取得显著改进。提高围绕福利的术语清晰度不仅履行了我们的道德义务，还支持了研究目标，并提供了对表型的可搜索描述。维康信托桑格研究所和剑桥大学（医学系 - 分子生物学实验室）之间的合作促成了斑马鱼福利术语的创建，从而实现术语的标准化。
