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[毛蕊异黄酮生物活性的研究成果]

[Research achievements on biological activities of calycosin].

作者信息

Zhang Dong-qing, Wang Hai-bao, Wang Shu-fang, Wang De-qing

出版信息

Zhongguo Zhong Yao Za Zhi. 2015 Nov;40(22):4339-45.

PMID:27097403
Abstract

Calycosin, which is a kind of typical phytoestrogen, can bind with estrogen receptor and produce estrogen-like effects. Calycosin were reported to have antioxidant, anti-osteoporosis, anti-tumor and immunomodulating activities. This review covers biological activities and its mechanism of calycosin. It will provide a useful reference for clinical research and rational utilization of monomericompound.

摘要

毛蕊异黄酮是一种典型的植物雌激素,可与雌激素受体结合并产生类雌激素效应。据报道,毛蕊异黄酮具有抗氧化、抗骨质疏松、抗肿瘤和免疫调节活性。本文综述了毛蕊异黄酮的生物学活性及其作用机制。它将为单体化合物的临床研究和合理利用提供有益的参考。

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1
[Research achievements on biological activities of calycosin].[毛蕊异黄酮生物活性的研究成果]
Zhongguo Zhong Yao Za Zhi. 2015 Nov;40(22):4339-45.
2
Calycosin Rebalances Advanced Glycation End Products-Induced Glucose Uptake Dysfunction of Hepatocyte In Vitro.毛蕊异黄酮体外调节晚期糖基化终末产物诱导的肝细胞葡萄糖摄取功能障碍
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Calycosin stimulates proliferation of estrogen receptor-positive human breast cancer cells through downregulation of Bax gene expression and upregulation of Bcl-2 gene expression at low concentrations.毛蕊异黄酮在低浓度时通过下调 Bax 基因表达和上调 Bcl-2 基因表达来刺激雌激素受体阳性的人乳腺癌细胞增殖。
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[Effects and mechanisms of total flavonoids of astragali radix and calycosin on inhibiting human erythroleukemia cell line K562].黄芪总黄酮及毛蕊异黄酮抑制人红白血病细胞株K562的作用及机制
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Inhibitory effects of two major isoflavonoids in Radix Astragali on high glucose-induced mesangial cells proliferation and AGEs-induced endothelial cells apoptosis.黄芪两种主要异黄酮类成分对高糖诱导的系膜细胞增殖及 AGEs 诱导的内皮细胞凋亡的抑制作用。
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A comparative study on the effect of promoting the osteogenic function of osteoblasts using isoflavones from Radix Astragalus.黄芪异黄酮促进成骨细胞成骨功能的比较研究。
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Calycosin: a Review of its Pharmacological Effects and Application Prospects.毛蕊异黄酮:药理学作用及应用前景的综述。
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Investigation of effects and mechanisms of total flavonoids of Astragalus and calycosin on human erythroleukemia cells.黄芪总黄酮和毛蕊异黄酮对人红白血病细胞作用及其机制的研究。
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Calycosin, a Common Dietary Isoflavonoid, Suppresses Melanogenesis through the Downregulation of PKA/CREB and p38 MAPK Signaling Pathways.毛蕊异黄酮,一种常见的膳食异黄酮,通过下调 PKA/CREB 和 p38 MAPK 信号通路来抑制黑色素生成。
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Calycosin improves cognitive function in a transgenic mouse model of Alzheimer's disease by activating the protein kinase C pathway.刺芒柄花素通过激活蛋白激酶C途径改善阿尔茨海默病转基因小鼠模型的认知功能。
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