Yuan Yi, Liu Min, Chen Ru-juan, Wei Feng-hua, Li Gui-lin, Li Jian-qiang, Xu Xing-jian
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2015 Dec;27(6):575-8.
To evaluate the acute toxicity of 10% LDS, a new molluscicide, to non-target organisms.
Based on "Chemical pesticide environmental safety test evaluation standard", an acute toxicity test was carried out with Coturnix coturnix japonica (quail), Apis mellifera L (bee), Bombyx mori (silkworm), and Brachydonio rerio (zebra fish) , and the skin stimulus test was also performed with guinea pig.
The quails had no toxic symptoms while the maximum poisoning concentration of LDS was 200 mg/kg (no toxicity). LC₅₀ of bees was 2.68 x 10³ mg/L (low toxicity). After 96 hours, no silkworms died in each group of different concentrations of LDS while the most concentration was 6.00 x 10² mg/kg, but there were some toxic symptoms such as inappetence and inactive in the high concentration group as compared to the blank control group (low toxic). LC₅₀ (96 h) of zebra fish was 6.16 mg/L (medium toxicity).
LDS has no toxicity to Coturnix coturnix japonica, low toxicity to Apis mellifera L and Bombyx mori, and medium toxicity to Brachydonio rerio. Compared with niclosamide ethanolamine salt, the toxicity to the fish is lower, and therefore, it is more suitable for the field application.
