Hashmi Muhammad Almas, Hussain Tanveer, Masood Najaf, Younas Muhammad, Asghar Rai Muhammad, Shafi Muhammad Shoaib
Department of Paediatric Gastroenterology, The Children's Hospital and The Institute of Child Health, Lahore.
Department of Medicine, Benazir Bhutto Hospital, Rawalpindi.
J Coll Physicians Surg Pak. 2016 Apr;26(4):263-6.
To determine the accuracy of anti-tissue transglutaminase IgA (TTG) antibody titer in the diagnosis of celiac disease, taking small intestine histopathology as the gold standard.
Cross-sectional analytical study.
Department of Paediatrics, Benazir Bhutto Hospital, Rawalpindi, from February to July 2013.
Sixty patients aged 2 - 13 years, admitted in the Paediatric Department of Benazir Bhutto Hospital, Rawalpindi, having at least 3 features from chronic diarrhea, malnutrition, short stature, anemia, abdominal distension and clubbing, were included. Age, gender, weight and height were recorded. Abdominal distension and clubbing were clinically noted. For hemoglobin, blood complete picture was done. For determination of nutritional status and short stature, standard centile charts were used. TTG titer upper GI endoscopy, duodenal biopsy, and histopathology were done in all cases.
There were 60 patients; 32 males, 28 females with mean age of 5.85 ±3.36 years. Frequency of CD was 63.33% in study population. Sensitivity of TTG was 86.84%, with 81.82% specificity, 89.19% positive predictive value, and 78.26% negative predictive value for diagnosing CD. TTG titre more than 50 iu/ml had a 100% positive predictive value.
TTG is an excellent screening test for the diagnosis of paediatric CD. TTG value > 50 IU/ml has 100% positive predictive value.
以小肠组织病理学为金标准，确定抗组织转谷氨酰胺酶IgA（TTG）抗体滴度在乳糜泻诊断中的准确性。
横断面分析研究。
2013年2月至7月，拉瓦尔品第贝娜齐尔·布托医院儿科。
纳入在拉瓦尔品第贝娜齐尔·布托医院儿科住院的60例2至13岁患者，这些患者至少具有慢性腹泻、营养不良、身材矮小、贫血、腹胀和杵状指这3项特征。记录年龄、性别、体重和身高。临床记录腹胀和杵状指情况。进行血常规检查以测定血红蛋白。使用标准百分位数图表确定营养状况和身材矮小情况。所有病例均进行TTG滴度、上消化道内镜检查、十二指肠活检和组织病理学检查。
共有60例患者，其中男性32例，女性28例，平均年龄5.85±3.36岁。研究人群中乳糜泻的发生率为63.33%。TTG诊断乳糜泻的敏感性为86.84%，特异性为81.82%，阳性预测值为89.19%，阴性预测值为78.26%。TTG滴度大于50 iu/ml的阳性预测值为100%。
TTG是诊断儿童乳糜泻的优秀筛查试验。TTG值>50 IU/ml的阳性预测值为100%。
