Let-7微小RNA在肿瘤发生和干细胞潜能方面的见解。

Sun Xin, Liu Jian, Xu Chongwen, Tang Shou-Ching, Ren Hong

Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.

Department of Otorhinolaryngology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.

J Cell Mol Med. 2016 Sep;20(9):1779-88. doi: 10.1111/jcmm.12861. Epub 2016 Apr 21.

The ability of the classic tumour-suppressive let-7 family to inhibit carcinogenesis, tumour progression, recurrence and pluripotency of cancer stem cells has generated significant interest in the field of cancer research. Through suppressing and degrading downstream-targeted mRNAs, let-7 affected most aspects of cell biology. It is perplexing how let-7 affects oncogenesis, as the large influx of new miRNAs and other kinds of non-coding RNAs are continuously defined. In this review, we delineate the complex functions of let-7 and discuss the future direction of let-7 research.

经典的肿瘤抑制性let-7家族抑制癌症发生、肿瘤进展、复发及癌症干细胞多能性的能力，已在癌症研究领域引起了广泛关注。通过抑制和降解下游靶向mRNA，let-7影响了细胞生物学的大多数方面。随着新的miRNA和其他种类非编码RNA不断被发现，let-7如何影响肿瘤发生令人困惑。在本综述中，我们阐述了let-7的复杂功能，并讨论了let-7研究的未来方向。