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两阶段方案及间隔器植入治疗髋关节破坏性化脓性关节炎

Two-stage protocol and spacer implantation in the treatment of destructive septic arthritis of the hip joint.

作者信息

Anagnostakos Konstantinos, Duchow Luise, Koch Katrin

机构信息

Klinik für Orthopädie und Orthopädische Chirurgie, Universitätsklinikum des Saarlandes, Kirrbergerstr. 100, 66421, Homburg, Saar, Germany.

出版信息

Arch Orthop Trauma Surg. 2016 Jul;136(7):899-906. doi: 10.1007/s00402-016-2455-3. Epub 2016 Apr 21.

Abstract

INTRODUCTION

The ideal treatment of the destructive septic arthritis of the hip joint remains controversial. The aim of the present retrospective study was to report on our experience about the use of antibiotic-loaded cement spacers in the treatment of destructive bacterial coxitis.

MATERIALS AND METHODS

22 consecutive patients (11 male, 11 female, mean age 59.7 years) have been treated with a two-stage protocol and implantation of an antibiotic-loaded cement spacer. All patients' records have been retrospectively evaluated with regard to comorbidities/predisposing factors, infection cause, causative pathogen organism, presence of a psoas abscess, surgical time of spacer implantation, duration of spacer implantation, spacer articulation, impregnation of bone cement, systemic antibiotic therapy, surgical time of prosthesis implantation, implant type, complications, and infection control rate.

RESULTS

The most common identified organism was Staphylococcus aureus (73 %). The mean duration of spacer implantation was 88 days. Spacer-specific complications were observed in 23 % of the cases and spacer non-specific ones in 50 % between stages. The mortality rate after the first stage was 18 %. Prosthesis implantation was performed in 16 cases. At a mean follow-up of 44.8 (12-120) months, the primary infection control rate (after one spacer implantation) was 87 % (13/15) and the secondary infection control rate (after two spacer implantations) 100 %.

CONCLUSIONS

Two-stage treatment and spacer implantation is associated with a high rate of infection control but also with a high mortality rate between stages.

摘要

引言

髋关节破坏性化脓性关节炎的理想治疗方法仍存在争议。本回顾性研究的目的是报告我们在使用抗生素骨水泥间隔物治疗破坏性细菌性髋关节炎方面的经验。

材料与方法

连续22例患者(男11例,女11例,平均年龄59.7岁)接受了两阶段方案治疗并植入抗生素骨水泥间隔物。所有患者的记录均已回顾性评估,涉及合并症/易感因素、感染原因、致病病原体、腰大肌脓肿的存在、间隔物植入手术时间、间隔物植入持续时间、间隔物关节连接、骨水泥浸渍、全身抗生素治疗、假体植入手术时间、植入物类型、并发症和感染控制率。

结果

最常见的病原体是金黄色葡萄球菌(73%)。间隔物植入的平均持续时间为88天。23%的病例观察到间隔物特异性并发症,50%的病例在两阶段之间观察到间隔物非特异性并发症。第一阶段后的死亡率为18%。16例患者进行了假体植入。平均随访44.8(12 - 120)个月时,初次感染控制率(一次间隔物植入后)为87%(13/15),二次感染控制率(两次间隔物植入后)为100%。

结论

两阶段治疗和间隔物植入与高感染控制率相关,但两阶段之间的死亡率也很高。

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