Câmara Antônio Carlos Lopes, do Vale André Menezes, Mattoso Cláudio Roberto Scabelo, Melo Marília Martins, Soto-Blanco Benito
Hospital Veterinário, Universidade Federal Rural do Semi-Árido (UFERSA), Av. Francisco Mota 572, Mossoró, RN, 59625-900, Brazil.
Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Avenida Antônio Carlos 6627, Belo Horizonte, MG, 30123-970, Brazil.
Trop Anim Health Prod. 2016 Jun;48(5):1037-42. doi: 10.1007/s11250-016-1039-0. Epub 2016 Apr 21.
Cottonseed cake contains gossypol, a potentially toxic compound that, when consumed by sheep, can affect reproduction, the immune system, and the liver. Changes in hematologic and serum biochemical parameters were monitored for 63 days in 12 Santa Inês ewes, six of which received ration containing 400 g kg(-1) of cottonseed cake. Blood samples were collected at the start of the experiment and weekly thereafter for hematologic assessment and determination of serum urea, creatinine, total protein, and albumin concentrations and for measurement of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyl transferase activities. No clinical signs of toxicity were observed. Evaluation of the erythron showed that sheep consuming cottonseed cake had an increased packed cell volume (p < 0.05) and increased erythrocyte counts and hemoglobin concentrations (p < 0.05) in the leukogram and serum biochemistry panel. In conclusion, consumption of 400 g kg(-1) cottonseed cake by sheep for 63 days may induce changes in the erythron but no consistent changes in serum biochemical parameters, indicating no damage to the liver or kidneys.
棉籽饼含有棉酚，这是一种潜在的有毒化合物，绵羊食用后会影响生殖、免疫系统和肝脏。对12只圣伊内斯母羊的血液学和血清生化参数变化进行了63天的监测，其中6只母羊的日粮中含有400 g kg(-1)的棉籽饼。在实验开始时采集血样，此后每周采集一次，用于血液学评估以及测定血清尿素、肌酐、总蛋白和白蛋白浓度，并测量丙氨酸转氨酶、天冬氨酸转氨酶、碱性磷酸酶和γ-谷氨酰转移酶活性。未观察到中毒的临床症状。红细胞系评估显示，食用棉籽饼的绵羊红细胞压积增加（p < 0.05），白细胞计数和血红蛋白浓度增加（p < 0.05），在白细胞分类计数和血清生化指标中也是如此。总之，绵羊食用400 g kg(-1)棉籽饼63天可能会引起红细胞系的变化，但血清生化参数没有持续变化，表明对肝脏或肾脏没有损害。
