器官型脑培养物中人类神经元的光遗传学控制。

Andersson My, Avaliani Natalia, Svensson Andreas, Wickham Jenny, Pinborg Lars H, Jespersen Bo, Christiansen Søren H, Bengzon Johan, Woldbye David P D, Kokaia Merab

Epilepsy Centre, Department of Clinical Sciences, Lund University Hospital, Lund, Sweden.

Lund Stem Cell Center, BMC B10 and Department of Neurosurgery, Lund University Hospital, Lund, Sweden.

Sci Rep. 2016 Apr 21;6:24818. doi: 10.1038/srep24818.

Optogenetics is one of the most powerful tools in neuroscience, allowing for selective control of specific neuronal populations in the brain of experimental animals, including mammals. We report, for the first time, the application of optogenetic tools to human brain tissue providing a proof-of-concept for the use of optogenetics in neuromodulation of human cortical and hippocampal neurons as a possible tool to explore network mechanisms and develop future therapeutic strategies.

光遗传学是神经科学中最强大的工具之一，可对包括哺乳动物在内的实验动物大脑中的特定神经元群体进行选择性控制。我们首次报道了将光遗传学工具应用于人类脑组织，为光遗传学在人类皮层和海马神经元神经调节中的应用提供了概念验证，这可能是一种探索网络机制和制定未来治疗策略的工具。