Nie Kechao, Xing Zhihua, Huang Wei, Wang Weihao, Liu Weiping
Institute of Integrated Medicine, Xiangya Hospital, Central South University, Changsha, Hunan Province, China -
Minerva Med. 2016 Apr 21.
Inconsistent results on the relationship between coffee consumption and pancreatic cancer risk has been reported in both epidemiological studies and previous meta-analyses. This updated meta-analyses was conducted to assess the association of coffee intake with pancreatic cancer risk. We evaluated the relationship of coffee ingestion and pancreatic cancer risk by performing a meta-analysis of prospective cohort studies and made an explicit document search in the PubMed database before November 2015. We also obtained prospective cohort studies of previous meta-analyses. A random-effects model was used for pooling overall relative risk. Twenty articles of coffee ingestion and pancreatic cancer were contained in our meta-analysis. The summary relative risk (RR) of pancreatic cancer and coffee intake of the highest compared with lowest category was 0.99 (95% CI = 0.81-1.21), with statistically moderate heterogeneity (I2 = 47.9%, P = 0.008). The heterogeneity reduced to I2 = 38.5% after excluding one studies, and the RR was 1.06 (95% CI = 0.94-1.20). The relationships of coffee intake and pancreatic risk did not modified by geographic areas, sex of participants, number of cases, follow-up years, and the number of adjusted confounders. Dose-response analysis indicated that every one-cup increase in coffee consumption was associated with an 1% increase in pancreatic cancer risk. No statistically significant publication biases existed. Coffee consumption may weakly increase the risk of pancreatic cancer.
流行病学研究和既往的荟萃分析均报告了咖啡摄入量与胰腺癌风险之间的结果不一致。本更新的荟萃分析旨在评估咖啡摄入量与胰腺癌风险之间的关联。我们通过对前瞻性队列研究进行荟萃分析来评估咖啡摄入与胰腺癌风险的关系，并于2015年11月之前在PubMed数据库中进行了明确的文献检索。我们还获取了既往荟萃分析中的前瞻性队列研究。采用随机效应模型合并总体相对风险。我们的荟萃分析纳入了20篇关于咖啡摄入与胰腺癌的文章。与最低类别相比，最高类别咖啡摄入量与胰腺癌的汇总相对风险（RR）为0.99（95%CI=0.81-1.21），具有统计学上中等程度的异质性（I2=47.9%，P=0.008）。排除一项研究后，异质性降至I2=38.5%，RR为1.06（95%CI=0.94-1.20）。咖啡摄入量与胰腺癌风险的关系不受地理区域、参与者性别、病例数、随访年限以及调整后的混杂因素数量的影响。剂量反应分析表明，咖啡摄入量每增加一杯，胰腺癌风险增加1%。不存在统计学上显著的发表偏倚。咖啡消费可能会轻微增加胰腺癌风险。
