Uzoma Ezeonwu Bertilla, Chukwubuikem Chinedu, Omoyibo Efe, Tagbo Oguonu
From the Department of Paediatrics, Federal Medical Centre, Asaba, Delta State, Nigeria.
Niger Postgrad Med J. 2016 Jan-Mar;23(1):1-5. doi: 10.4103/1117-1936.180108.
Diarrhoeal disease still remains one of the common causes of morbidity and mortality in children under 5 years of age. It is caused notably by the different serotypes of rotavirus.
To ascertain the prevalence and risk factors for rotavirus diarrhoea in children under 5 years of age seen at Federal Medical Centre, Asaba, and to determine the different serotypes and their relationship with diarrhoea severity.
A hospital-based cross-sectional study in which all children under 5 years of age, with diarrhoea had their stool samples tested for rotavirus antigen with enzyme immunoassay. Significant values of variables were determined using t-tests and Chi-square tests as appropriate.
One hundred and thirty-two children were studied: 52.3% were males and 46.7% were females. Children 1-11 months of age constitute 49.2%, whereas those 12-59 months were 50.8%. Only 49 (37.1%) children were ELISA positive for rotavirus and of this number, 31 (63.3%) were within 1-11 months of age, P = 0.013. The three most common rotavirus genotypes were G3P[6] in 24.5%, G1P[6] in 12.2% and G12P[8] in 10.2% of the samples, respectively. Duration of vomiting was more prolonged with G3P[6] infection, P = 0.029, whereas dehydration and the overall severity of the diarrhoea were more with G12P[8] infection, P = 0.026 and 0.010, respectively.
The emerging G12 rotavirus genotype was isolated in Asaba.
腹泻病仍是5岁以下儿童发病和死亡的常见原因之一。它主要由不同血清型的轮状病毒引起。
确定在阿萨巴联邦医疗中心就诊的5岁以下儿童轮状病毒腹泻的患病率和危险因素，并确定不同血清型及其与腹泻严重程度的关系。
一项基于医院的横断面研究，对所有5岁以下腹泻儿童的粪便样本进行酶免疫测定以检测轮状病毒抗原。根据情况使用t检验和卡方检验确定变量的显著值。
共研究了132名儿童：52.3%为男性，46.7%为女性。1至11个月大的儿童占49.2%，而12至59个月大的儿童占50.8%。只有49名（37.1%）儿童轮状病毒ELISA检测呈阳性，其中31名（63.3%）年龄在1至11个月之间，P = 0.013。三种最常见的轮状病毒基因型分别为G3P[6]（占样本的24.5%）、G1P[6]（占12.2%）和G12P[8]（占10.2%）。G3P[6]感染时呕吐持续时间更长，P = 0.029，而G12P[8]感染时脱水和腹泻总体严重程度更高，P分别为0.026和0.010。
在阿萨巴分离出了新出现的G12轮状病毒基因型。
