Price C H, Jeffree G M
Br J Cancer. 1977 Oct;36(4):511-22. doi: 10.1038/bjc.1977.221.
A study is presented of all cases of primary sarcoma of bone registered during the period 1946 to 1974 for a specified population resident in south-western England. Ninety-six per cent of the 365 cases were histologically and radiologically verified and are separated into 8 categories of sarcoma. The number of tumours presenting during each hemi-decade did not markedly diverge from the 5-year mean for the period, nor was any significant change found in tumour incidence during the last 20 years of the survey. The age, sex and site distributions correspond with those reported elsewhere. Age-specific incidence rates are compared with those published for Sweden. For osteosarcoma and Ewing's tumour, both commoner in young people, the two series agree closely up to age 55 years, after which the Swedish incidence rates rise and are not exceeded when, for the present cases, Paget's osteosarcomas are included. Whilst Paget's disease may change the age incidence of some types of bone sarcoma, it is uncertain whether it increases the total number which occur. Differences in tumour incidence between males and females, whether for a specific type or for all bone sarcomas, are seldom statistically significant, but the patterns appear to be consistent.
本文呈现了对1946年至1974年期间居住在英格兰西南部特定人群中登记的所有原发性骨肉瘤病例的研究。365例病例中有96%经组织学和放射学证实，并分为8类肉瘤。每半个十年出现的肿瘤数量与该时期的5年平均值没有明显差异，在调查的最后20年中也未发现肿瘤发病率有任何显著变化。年龄、性别和部位分布与其他地方报道的一致。将年龄特异性发病率与瑞典公布的发病率进行了比较。骨肉瘤和尤因肉瘤在年轻人中更为常见，在55岁之前，这两个系列的数据非常接近，55岁之后，瑞典的发病率上升，并且在纳入本病例中的佩吉特骨肉瘤后，瑞典的发病率没有被超过。虽然佩吉特病可能会改变某些类型骨肉瘤的年龄发病率，但不确定它是否会增加骨肉瘤的总数。男性和女性之间的肿瘤发病率差异，无论是针对特定类型还是所有骨肉瘤，在统计学上很少有显著差异，但模式似乎是一致的。
