Ye Han-shen, Xu Ru, Wang Min, Rong Xia, Hua Wen-feng, Ye Xin, Ruo Guang-ping, Fu Yong-shui
Department of Blood Transfusion, People's Hospital of Guangdong Province, Guangzhou, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2010 Dec;30(12):2655-7.
To determine the distribution of HCV genotypes among volunteer blood donors in Guangzhou.
Six-nine HCV RNA-positive samples were collected from volunteer blood donors in Guangzhou. NS5B fragments of HCV were amplified followed by DNA sequencing and phylogenetic analysis.
HCV genotypes were determined for 67 samples. Among them, the subtypes 1b, 2a, 3a, 3b, 6a and 6n were detected at the frequencies of 37.31%, 4.48%, 7.46%, 4.48%, 44.78% and 1.49%, respectively.
HCV 1b and 6a are the most predominant two subtypes among volunteer blood donors in Guangzhou.
确定广州无偿献血者中丙型肝炎病毒（HCV）基因型的分布情况。
从广州无偿献血者中收集69份HCV RNA阳性样本。扩增HCV的NS5B片段，随后进行DNA测序和系统发育分析。
对67份样本确定了HCV基因型。其中，1b、2a、3a、3b、6a和6n亚型的检测频率分别为37.31%、4.48%、7.46%、4.48%、44.78%和1.49%。
HCV 1b和6a是广州无偿献血者中最主要的两种亚型。
