Suppr超能文献

完全血运重建可提高八旬老人的生存率。

Complete Coronary Revascularization Improves Survival in Octogenarians.

作者信息

Melby Spencer J, Saint Lindsey L, Balsara Keki, Itoh Akinobu, Lawton Jennifer S, Maniar Hersh, Pasque Michael K, Damiano Ralph J, Moon Marc R

机构信息

Division of Cardiothoracic Surgery, Department of Surgery, Washington University in St. Louis, St. Louis, Missouri.

Division of Cardiothoracic Surgery, Department of Surgery, Washington University in St. Louis, St. Louis, Missouri.

出版信息

Ann Thorac Surg. 2016 Aug;102(2):505-11. doi: 10.1016/j.athoracsur.2016.01.065. Epub 2016 Apr 19.

Abstract

BACKGROUND

Completeness of revascularization is important for patients undergoing coronary artery bypass graft surgery, but information on its long-term impact in octogenarian patients is lacking.

METHODS

From 1986 to 2004, 525 consecutive patients aged 80 years or more (mean age 82 ± 3 years) underwent coronary artery bypass graft surgery and were followed for a minimum of 10 years or until death. Outcome was stratified based on extent of revascularization, defined as total (graft to every diseased vessel), complete (graft to each region but not every diseased vessel), or incomplete (bypass not done to all suitable regions or vessels).

RESULTS

Follow-up of 3,155 patient-years (mean follow-up 73 ± 54 months) was 99% complete. Overall operative mortality was 8% (41 of 525), and was lower for elective than for urgent/emergent cases (4.2% versus 16% ± 6%, p < 0.001, respectively). There was a trend toward higher operative mortality with incomplete (13% ± 6%) versus complete (8% ± 4%) or total revascularization (6% ± 3%; p = 0.09). For operative survivors, mean survival was significantly improved with total and complete revascularization (6.9 and 6.8 years, respectively), compared with incomplete revascularization (5.4 years, p < 0.008). For total, complete, and incomplete revascularization, survival at 5 years was 61% ± 3%, 61% ± 4%, and 47% ± 5%, respectively. Ten-year survival was 27% ± 3%, 21% ± 3%, and 16% ± 4% (p = 0.01), respectively, in these groups.

CONCLUSIONS

Incomplete revascularization in octogenarians is associated with decreased long-term survival when compared with total or complete revascularization. There was no survival benefit with total over complete revascularization. Octogenarians can have good long-term survival, especially with adequate revascularization.

摘要

背景

血管重建的完整性对于接受冠状动脉旁路移植术的患者很重要,但缺乏关于其对八旬患者长期影响的信息。

方法

1986年至2004年,525例连续的80岁及以上患者(平均年龄82±3岁)接受了冠状动脉旁路移植术,并至少随访10年或直至死亡。结局根据血管重建程度分层,血管重建程度定义为完全(移植至每根病变血管)、完整(移植至每个区域但并非每根病变血管)或不完整(未对所有合适区域或血管进行旁路移植)。

结果

3155患者年的随访(平均随访73±54个月)完成率为99%。总体手术死亡率为8%(525例中的41例),择期手术的死亡率低于急诊/紧急手术(分别为4.2%和16%±6%,p<0.001)。与完整(8%±4%)或完全血管重建(6%±3%)相比,不完整血管重建(13%±6%)的手术死亡率有升高趋势(p=0.09)。对于手术幸存者,与不完整血管重建(5.4年)相比,完全和完整血管重建后的平均生存期显著改善(分别为6.9年和6.8年,p<0.008)。对于完全、完整和不完整血管重建,5年生存率分别为61%±3%、61%±4%和47%±5%。在这些组中,10年生存率分别为27%±3%、21%±3%和16%±4%(p=0.01)。

结论

与完全或完整血管重建相比,八旬患者的不完整血管重建与长期生存率降低相关。完全血管重建与完整血管重建相比并无生存获益。八旬患者可获得良好的长期生存,尤其是进行充分的血管重建时。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验