Sonneveld P, van Lom K, Prins M E, Kappers-Klunne M C, Abels J
Ned Tijdschr Geneeskd. 1989 Mar 11;133(10):510-4.
Of twelve patients with malignant histiocytosis admitted between 1974 and 1987, clinical symptoms, diagnostic procedures and the course of the disease were retrospectively evaluated. Predominant findings at physical examination were fever (11/12), splenomegaly (12/12), hepatomegaly (8/12), and lymphadenopathy (8/12). Laboratory findings included anaemia, leukocytopenia, thrombocytopenia, high lactate dehydrogenase, and jaundice. Positive diagnostic procedures included biopsies or aspirates of bone marrow (11/12), spleen (6/10), liver (7/9), lymph node (4/4), skin (1/2), lung (1/1) and blood (2/12). In seven patients treated with combination chemotherapy an average survival of 540 days was observed, while two long-term disease-free survivals were accomplished.
对1974年至1987年间收治的12例恶性组织细胞增多症患者的临床症状、诊断方法及病程进行回顾性评估。体格检查的主要发现为发热（11/12）、脾肿大（12/12）、肝肿大（8/12）和淋巴结病（8/12）。实验室检查结果包括贫血、白细胞减少、血小板减少、高乳酸脱氢酶和黄疸。阳性诊断方法包括骨髓活检或穿刺（11/12）、脾脏（6/10）、肝脏（7/9）、淋巴结（4/4）、皮肤（1/2）、肺（1/1）和血液（2/12）。7例接受联合化疗的患者平均生存期为540天，同时有2例实现了长期无病生存。
