Du Jun-Rong, Long Fang-Yi, Chen Chu
Department of Pharmacology, West China School of Pharmacy, Sichuan University, Chengdu, P.R. China.
Department of Pharmacology, West China School of Pharmacy, Sichuan University, Chengdu, P.R. China.
Enzymes. 2014;36:95-130. doi: 10.1016/B978-0-12-802215-3.00006-9.
Triterpenoid saponins are glycosides with remarkable structural and bioactive diversity. They are becoming increasingly significant in the treatment of cancer due to their efficacy and safety. This chapter provides an update on the sources, pharmacological effects, structure-activity relationships, and clinical studies of anticancer triterpenoid saponins with a particular focus on the molecular mechanisms underlying their therapeutic properties. The correlative references and study reports described were collected through PubMed. The anticancer triterpenoid saponins enable the inhibition of cancer formation and progression by modulating multiple signaling targets related to cellular proliferation, apoptosis, autophagy, metastasis, angiogenesis, inflammation, oxidative stress, multidrug resistance, cancer stem cells, and microRNAs. This review provides new insights into the molecular basis of triterpenoid saponins in the chemoprevention and chemotherapy of cancer.
三萜皂苷是一类具有显著结构和生物活性多样性的糖苷。由于其有效性和安全性，它们在癌症治疗中变得越来越重要。本章提供了关于抗癌三萜皂苷的来源、药理作用、构效关系和临床研究的最新进展，特别关注其治疗特性背后的分子机制。所描述的相关参考文献和研究报告是通过PubMed收集的。抗癌三萜皂苷通过调节与细胞增殖、凋亡、自噬、转移、血管生成、炎症、氧化应激、多药耐药、癌症干细胞和微小RNA相关的多个信号靶点，从而抑制癌症的形成和进展。本综述为三萜皂苷在癌症化学预防和化疗中的分子基础提供了新的见解。
