Kawaguchi Moemi, Aoki Shigeki, Hirao Takuya, Morita Michie, Ito Kousei
Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba-shi, Chiba 260-8675, Japan.
Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba-shi, Chiba 260-8675, Japan.
Biochem Biophys Res Commun. 2016 May 20;474(1):188-192. doi: 10.1016/j.bbrc.2016.04.098. Epub 2016 Apr 20.
Most cancer cells predominantly produce energy by glycolysis, even in the presence of adequate oxygen. Therefore, inhibition of glycolysis is a promising cancer treatment target. Recently, it has been recognized that to conduct thorough treatment of cancer, comprehensive understanding of cancer metabolism is essential, not only focusing on glycolysis. Here, we investigated the supporting mechanism of autophagy, which is a catabolic process that recycles intracellular components, for energy supply in the glycolysis-inhibited condition. Autophagy is thought to be highly activated in cancers and to promote their growth or progression by adapting to the harsh surrounding microenvironment. We found that cancer cells positively promoted autophagy to overcome the energy shortage from glycolysis by maintaining mitochondrial activity for ATP production essential for survival. Conclusively, autophagy plays a role in determining whether cancer cells live or die, and autophagic ability in cancer cells is a promising target for therapy.
大多数癌细胞即使在有充足氧气的情况下也主要通过糖酵解产生能量。因此，抑制糖酵解是一个很有前景的癌症治疗靶点。最近，人们认识到，要对癌症进行彻底治疗，全面了解癌症代谢至关重要，而不仅仅关注糖酵解。在这里，我们研究了自噬（一种回收细胞内成分的分解代谢过程）在糖酵解抑制条件下为能量供应提供支持的机制。自噬被认为在癌症中高度激活，并通过适应恶劣的周围微环境促进其生长或进展。我们发现癌细胞通过维持对生存至关重要的ATP产生的线粒体活性，积极促进自噬以克服糖酵解导致的能量短缺。总之，自噬在决定癌细胞的生死中起作用，癌细胞的自噬能力是一个很有前景的治疗靶点。
