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衣原体的转化：当前的方法及其对我们理解衣原体感染生物学的影响。

Transformation of Chlamydia: current approaches and impact on our understanding of chlamydial infection biology.

机构信息

Department of Microbiology, Immunology & Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40536, USA.

Department of Microbiology, Immunology & Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40536, USA.

出版信息

Microbes Infect. 2018 Aug-Sep;20(7-8):445-450. doi: 10.1016/j.micinf.2018.01.002. Epub 2018 Feb 2.

DOI:10.1016/j.micinf.2018.01.002
PMID:29409975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6070436/
Abstract

The intonation "The king is dead, long live the king" aptly describes the state of Chlamydia research. Genetic-based approaches are rapidly replacing correlative strategies to provide new insights. We describe how current transformation technologies are enhancing progress in understanding Chlamydia infection biology and present key opportunities for further development.

摘要

“国王死了，国王万岁”这个成语恰当地描述了衣原体研究的现状。基于遗传学的方法正在迅速取代相关性策略，为人们提供新的见解。我们描述了当前的转化技术如何增强人们对衣原体感染生物学的理解，并提出了进一步发展的关键机会。

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本文引用的文献

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mSphere. 2017 Jul 19;2(4). doi: 10.1128/mSphere.00207-17. eCollection 2017 Jul-Aug.
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Nat Rev Microbiol. 2017 Sep;15(9):544-558. doi: 10.1038/nrmicro.2017.59. Epub 2017 Jun 19.
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The Chlamydia trachomatis type III secretion substrates CT142, CT143, and CT144 are secreted into the lumen of the inclusion.沙眼衣原体III型分泌底物CT142、CT143和CT144被分泌到包涵体腔内。
PLoS One. 2017 Jun 16;12(6):e0178856. doi: 10.1371/journal.pone.0178856. eCollection 2017.
4
Absence of Specific Chlamydia trachomatis Inclusion Membrane Proteins Triggers Premature Inclusion Membrane Lysis and Host Cell Death.沙眼衣原体特异性包涵体膜蛋白的缺失引发包涵体膜过早裂解和宿主细胞死亡。
Cell Rep. 2017 May 16;19(7):1406-1417. doi: 10.1016/j.celrep.2017.04.058.
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Chlamydia trachomatis Transformation and Allelic Exchange Mutagenesis.沙眼衣原体转化与等位基因交换诱变
Curr Protoc Microbiol. 2017 May 16;45:11A.3.1-11A.3.15. doi: 10.1002/cpmc.31.
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