Department of Anaesthesiology and Critical Care, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, 605006, India.
Departments of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, 605006, India.
Int J Surg. 2016 Jun;30:68-73. doi: 10.1016/j.ijsu.2016.04.030. Epub 2016 Apr 22.
To determine the incidence, morbidity and mortality due to Venous Thromboembolism (VTE) in surgical patients, and to assess the validity and reliability of Adapted Caprini scoring in risk stratification for VTE prophylaxis.
This was a prospective observational study in a tertiary care hospital of South India on patients who underwent both elective and emergency surgeries over a period of 9 months. An Adapted Caprini score was devised which included only the clinical criteria. The patients were scored by two persons independently at admission and followed up till the 30th post-operative day and primary and secondary end points were statistically analyzed.
Three hundred and one patients were included and the overall incidence of VTE at 30 days was 7.3%. The risk of developing VTE was found to be significantly higher among the >8 score group as compared to 3-4 group (OR = 153.5, p < 0.001), or the 5-6 group (OR = 52.9, p < 0.001) or the 7-8 group (OR = 2.3, p = 0.002). Patients with a score of 7-8 were more likely to develop VTE as compared to 3-4 group (OR = 67.5, p < 0.001) or the 5-6 group (OR = 23.2, p < 0.001).
The risk of developing VTE is less significant in the 5-6 score group compared to 7-8 or more score group. Further stratification of the highest risk groups is recommended to provide appropriate prophylaxis only to the patients with high scores, thereby reducing complications due to VTE prophylaxis.
确定手术患者静脉血栓栓塞症(VTE)的发病率、患病率和死亡率,并评估改良 Caprini 评分在 VTE 预防风险分层中的有效性和可靠性。
这是印度南部一家三级保健医院进行的前瞻性观察性研究,纳入了在 9 个月期间接受择期和急诊手术的患者。设计了一种改良 Caprini 评分,仅包括临床标准。两名人员在入院时对患者进行独立评分,并随访至术后第 30 天,对主要和次要终点进行统计学分析。
共纳入 310 例患者,术后 30 天 VTE 的总发生率为 7.3%。与 3-4 分组相比,>8 分组发生 VTE 的风险显著更高(OR=153.5,p<0.001),或 5-6 分组(OR=52.9,p<0.001)或 7-8 分组(OR=2.3,p=0.002)。7-8 分组患者发生 VTE 的可能性高于 3-4 分组(OR=67.5,p<0.001)或 5-6 分组(OR=23.2,p<0.001)。
与 7-8 或更高分组相比,5-6 分组发生 VTE 的风险较小。建议对最高风险组进一步分层,仅对高分组患者提供适当的预防措施,从而减少因 VTE 预防而导致的并发症。