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基于美国人群队列研究的髋症状和三种髋骨关节炎结局的年发生率:约翰斯顿县骨关节炎项目。

Annual incidence rates of hip symptoms and three hip OA outcomes from a U.S. population-based cohort study: the Johnston County Osteoarthritis Project.

机构信息

Department of Mathematics and Statistics, Georgia State University, Atlanta, GA, USA.

Division of Population Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.

出版信息

Osteoarthritis Cartilage. 2016 Sep;24(9):1518-27. doi: 10.1016/j.joca.2016.04.012. Epub 2016 Apr 21.

Abstract

OBJECTIVE

Estimate annual incidence rates (IRs) of hip symptoms and three osteoarthritis (OA) outcomes (radiographic, symptomatic, and severe radiographic) overall and by race, sociodemographic characteristics, and hip OA risk factors.

DESIGN

Analyze baseline (1991-1997) and first follow-up (1999-2003) data (n = 1446) from the Johnston County Osteoarthritis Project, a population-based, prospective study of adults ≥45 years in North Carolina. Hip symptoms were pain, aching, and/or stiffness on most days, or groin pain. Radiographic and severe radiographic OA were Kellgren-Lawrence (KL) grades ≥2 and ≥3, respectively. Symptomatic OA was radiographic OA with symptoms in the same hip. Sociodemographics were age, gender, race, highest attained education, and annual household income. Hip OA risk factors were self-reported body mass index (BMI) at age 18 years, clinically measured BMI at baseline, and history of hip injury.

RESULTS

Annual IRs (median = 5.5 years follow-up) were 37, 23, 13, and 2.9 per 1000 person-years for hip symptoms, and radiographic, symptomatic, and severe radiographic hip OA, respectively. We found low IRs of radiographic and symptomatic hip OA among African Americans and high IRs of hip symptoms among the obese and the very poor. Across outcomes, IRs were highest for those with hip injury.

CONCLUSION

No prior studies have reported IRs of hip symptoms; IRs of radiographic and severe radiographic hip OA were similar to, and the IR of symptomatic hip OA was higher than, previous estimates. Prevention efforts should target low socioeconomic status (SES) populations and obese adults; interventions for hip OA and hip symptoms are imperative for those with hip injuries.

摘要

目的

总体上及按种族、社会人口学特征和髋关节炎危险因素估算髋症状和三种骨关节炎(OA)结局(放射学、症状性和严重放射学)的年发生率(IR)。

设计

分析北卡罗来纳州约翰斯顿县骨关节炎项目的基线(1991-1997 年)和第一次随访(1999-2003 年)数据(n=1446),该项目是一项针对 45 岁及以上成年人的基于人群的前瞻性研究。髋症状为多数日子出现疼痛、酸痛和/或僵硬,或腹股沟疼痛。放射学和严重放射学 OA 分别为 Kellgren-Lawrence(KL)分级≥2 和≥3。症状性 OA 是放射学 OA 且同一髋关节出现症状。社会人口学特征为年龄、性别、种族、最高受教育程度和年家庭收入。髋关节炎危险因素为 18 岁时的自我报告体重指数(BMI)、基线时的临床测量 BMI 和髋部受伤史。

结果

髋症状、放射学、症状性和严重放射学髋关节炎的年发生率(中位数=5.5 年随访)分别为 37、23、13 和 2.9/1000 人年。我们发现非裔美国人放射学和症状性髋关节炎的发生率较低,肥胖和非常贫困人群的髋症状发生率较高。在所有结局中,髋部受伤者的发生率最高。

结论

先前的研究没有报告髋症状的 IR;放射学和严重放射学髋关节炎的 IR 与先前的估计相似,症状性髋关节炎的 IR 高于先前的估计。预防工作应针对低社会经济地位(SES)人群和肥胖成年人;对于髋部受伤者,干预髋关节炎和髋部症状至关重要。

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