硫酸纤维素可提高大鼠体内激肽的血药浓度。

Cellulose sulfate increases blood concentration of kinins in rats.

作者信息

Barabé J, Huberdeau D

机构信息

Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, Québec, Canada.

出版信息

Res Commun Chem Pathol Pharmacol. 1989 Feb;63(2):281-4.

PMID:2711029

Abstract

Intravenous injection of cellulose sulfate (CS) in rats induced a dose-dependent decrease of blood pressure accompanied by a concomitant increase of circulating levels of immunoreactive bradykinin (BK) from a level of 52 pg/mL of blood in control animals to 400 pg/mL in the group injected with 3.0 mg/kg of CS. An increase of desArg9BK was also observed while the blood concentration of BK(1-7) remained constant. Kinins contents in acidic extracts of lungs increased slightly while renal kinins from the same animals showed a slight decrease. The results suggest that plasma kallikrein-kinin system mediates CS-induced hypotension and that glandular kallikreins do not participate to the hypotensive action of CS.

摘要

给大鼠静脉注射硫酸纤维素（CS）可导致血压呈剂量依赖性下降，同时循环中免疫反应性缓激肽（BK）水平随之升高，从对照动物血液中52 pg/mL的水平升至注射3.0 mg/kg CS组的400 pg/mL。还观察到去精氨酸9缓激肽增加，而BK(1-7)的血浓度保持恒定。肺酸性提取物中的激肽含量略有增加，而同一动物的肾脏激肽则略有下降。结果表明，血浆激肽释放酶-激肽系统介导CS诱导的低血压，而腺体激肽释放酶不参与CS的降压作用。