Moraes Milton R, Bacurau Reury F P, Ramalho João D S, Reis Felipe C G, Casarini Dulce E, Chagas Jair R, Oliveira Vitor, Higa Elisa Mieko S, Abdalla Dulcinéia S P, Pesquero Jorge L, Pesquero João B, Araujo Ronaldo C
Department of Biophysics, Federal University of São Paulo, São Paulo, Brazil.
Biol Chem. 2007 May;388(5):533-40. doi: 10.1515/BC.2007.055.
Post-exercise hypotension is an important event for blood pressure regulation, especially in hypertensive individuals. Although post-exercise hypotension is a well-known phenomenon, the mechanism responsible is still unclear. The kallikrein-kinin system is involved in blood pressure control, but its role in post-exercise hypotension has not yet been investigated. Thus, the purpose of this study was to investigate the involvement of the vasodilators bradykinin and des-Arg(9)-BK and kallikrein activity in post-exercise hypotension promoted by 35 min of cycle ergometer (CE) or circuit weight-training (CWT) bouts in normotensive and hypertensive individuals. A significant decrease in mean arterial pressure at 45 and 60 min after CE and 45 min after CWT was observed in normotensive individuals. Hypertensive values of mean arterial pressure were significantly reduced at 45 and 60 min after CE and at 60 min after CWT. Before exercise, plasma bradykinin concentrations and kallikrein activity were higher in hypertensive compared to normotensive volunteers. Kinin levels increased in the groups evaluated at the end of the training period and 60 min post-exercise. These data suggest that the kallikrein-kinin system may be involved in post-exercise hypotension in normotensive and hypertensive individuals subjected to CE and CWT bouts.
运动后低血压是血压调节中的一个重要事件，尤其是在高血压患者中。尽管运动后低血压是一个众所周知的现象，但其背后的机制仍不清楚。激肽释放酶-激肽系统参与血压控制，但其在运动后低血压中的作用尚未得到研究。因此，本研究的目的是调查血管舒张剂缓激肽、去精氨酸（9）-缓激肽和激肽释放酶活性在正常血压和高血压个体进行35分钟的蹬车测力计（CE）或循环重量训练（CWT）后引发的运动后低血压中的作用。在正常血压个体中，观察到CE后45分钟和60分钟以及CWT后45分钟时平均动脉压显著下降。CE后45分钟和60分钟以及CWT后60分钟时，高血压患者的平均动脉压显著降低。运动前，高血压志愿者的血浆缓激肽浓度和激肽释放酶活性高于正常血压志愿者。在训练期结束时和运动后60分钟评估的组中，激肽水平升高。这些数据表明，激肽释放酶-激肽系统可能参与了正常血压和高血压个体在进行CE和CWT后出现的运动后低血压。
