补充ω-3对多囊卵巢综合征女性内脂素、脂联素及人体测量指标的影响
Effect of Omega-3 Supplementation on Visfatin, Adiponectin, and Anthropometric Indices in Women with Polycystic Ovarian Syndrome.
作者信息
Nadjarzadeh Azadeh, Dehghani-Firouzabadi Razieh, Daneshbodi Hoorieh, Lotfi Mohammad Hassan, Vaziri Niloofar, Mozaffari-Khosravi Hassan
机构信息
Nutrition and Food Security Research Centre, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Department of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
出版信息
J Reprod Infertil. 2015 Oct-Dec;16(4):212-20.
BACKGROUND
Polycystic ovary syndrome (PCOS) is a multifactorial, metabolic disorder. Characteristics are chronic anovulation, polycystic ovaries and hyperandrogenism. The aim of this study was to determine the effect of omega-3 supplementation on visfatin, adiponectin, and anthropometric indices in PCOS women.
METHODS
The study was a randomized double blind placebo-controlled clinical trial. It was conducted on 84 women with polycystic ovary syndrome (26.92±5.05 years, BMI=31.69 Kg/m (2)) who referred to the fertility and infertility research center and Shahid Sadoughi hospital in Yazd. After the examination, evaluation and para-medical assessment by obstetrician, they were recruited. They took 3 capsules of omega-3 (each one contained 180 mg EPA and 120 mg DHA) or placebo (each contained 1 g paraffin) daily for 8 weeks. Statistical analysis was paired T-test and student T-test, and a p<0.05 was considered statistically significant.
RESULTS
After the intervention, visfatin concentration did not change in neither groups. But, at the end of the study, the mean of adiponectin concentration increased (p<0.001) in omega-3 group. Moreover, the mean of changes in this factor was significantly different between groups (p<0.005). FSH did not change in two groups of the study. However, the mean of LH decreased about 1.74 mlU/ml in omega-3 group (p<0.005). The mean of change of LH/FSH ratio between groups was significant (p<0.05). After the intervention, prolactin did not meaningfully change in both groups.
CONCLUSION
Our results showed that 8 weeks of supplementation of omega-3 may have some beneficial effects on PCOS biochemical characteristics such as LH, LH/FSH, and adiponectin.
背景
多囊卵巢综合征（PCOS）是一种多因素代谢紊乱疾病。其特征为慢性无排卵、多囊卵巢和高雄激素血症。本研究旨在确定补充ω-3对PCOS女性内脂素、脂联素和人体测量指标的影响。
方法
本研究为随机双盲安慰剂对照临床试验。对84名多囊卵巢综合征女性（年龄26.92±5.05岁，体重指数=31.69 Kg/m²）进行了研究，这些女性前往亚兹德的生育与不孕研究中心及沙希德·萨杜基医院就诊。经产科医生检查、评估和辅助医学评估后，将她们纳入研究。她们每天服用3粒ω-3胶囊（每粒含180毫克二十碳五烯酸和120毫克二十二碳六烯酸）或安慰剂（每粒含1克石蜡），持续8周。统计分析采用配对t检验和学生t检验，p<0.05被认为具有统计学意义。
结果
干预后，两组的内脂素浓度均未改变。但是，在研究结束时，ω-3组脂联素浓度的平均值有所增加（p<0.001）。此外，两组间该因子变化的平均值存在显著差异（p<0.005）。研究的两组中促卵泡激素（FSH）均未改变。然而，ω-3组促黄体生成素（LH）的平均值下降了约1.74 mIU/ml（p<0.005）。两组间LH/FSH比值变化的平均值具有显著性（p<0.05）。干预后，两组的催乳素均无明显变化。
结论
我们的结果表明，补充8周ω-3可能对PCOS的生化特征如LH、LH/FSH和脂联素具有一些有益影响。
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