患有慢性肾病、癌症、淋巴瘤和内毒素血症的犬类中的中性粒细胞明胶酶相关脂质运载蛋白
Neutrophil gelatinase-associated lipocalin in dogs with chronic kidney disease, carcinoma, lymphoma and endotoxaemia.
作者信息
Cobrin A R, Blois S L, Abrams-Ogg A C G, Kruth S A, Dewey C, Holowaychuk M K, Gauthier V
机构信息
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
出版信息
J Small Anim Pract. 2016 Jun;57(6):291-8. doi: 10.1111/jsap.12481. Epub 2016 Apr 26.
OBJECTIVES
To measure serum and urine neutrophil gelatinase-associated lipocalin (NGAL) concentrations in healthy dogs and dogs with chronic kidney disease, neoplasia and endotoxaemia.
METHODS
Serum and urine NGAL concentrations were measured in 42 healthy dogs, 11 dogs with chronic kidney disease, 12 dogs with carcinoma, 20 dogs with lymphoma and 15 dogs with lipopolysaccharide-induced endotoxaemia. In dogs with chronic kidney disease, NGAL was measured 3 and 6 months later.
RESULTS
Compared with healthy controls, dogs with chronic kidney disease (PÄ0·0008), carcinoma (PÄ0·0072) and lymphoma (PÄ0·0008) had elevated serum and urine NGAL and urine NGAL-to-creatinine ratio. Serum and urine NGAL was not significantly different between dogs with chronic kidney disease, carcinoma or lymphoma (Pê0·12). In dogs with non-progressive chronic kidney disease, NGAL concentrations did not change significantly over the 6-month study period.
CLINICAL SIGNIFICANCE
NGAL can be elevated by chronic kidney disease and neoplasia, compared with healthy controls. Further research is needed to determine if uNGAL or uNGAL-to-creatinine ratio is more specific than serum levels to detect chronic kidney disease.
目的
测定健康犬以及患有慢性肾病、肿瘤和内毒素血症的犬的血清和尿液中中性粒细胞明胶酶相关脂质运载蛋白（NGAL）的浓度。
方法
对42只健康犬、11只患有慢性肾病的犬、12只患有癌症的犬、20只患有淋巴瘤的犬以及15只由脂多糖诱导产生内毒素血症的犬，测定其血清和尿液中NGAL的浓度。对于患有慢性肾病的犬，在3个月和6个月后再次测量NGAL。
结果
与健康对照组相比，患有慢性肾病（P≤0.0008）、癌症（P≤0.0072）和淋巴瘤（P≤0.0008）的犬，其血清和尿液中的NGAL以及尿液中NGAL与肌酐的比值均升高。患有慢性肾病、癌症或淋巴瘤的犬之间，血清和尿液中的NGAL无显著差异（P≥0.12）。在患有非进行性慢性肾病的犬中，在6个月的研究期内，NGAL浓度无显著变化。
临床意义
与健康对照组相比，慢性肾病和肿瘤可使NGAL升高。需要进一步研究以确定尿NGAL或尿NGAL与肌酐的比值在检测慢性肾病方面是否比血清水平更具特异性。
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