感染性疾病与冠状动脉疾病。
Infectious and coronary artery disease.
作者信息
Rezaee-Zavareh Mohammad Saeid, Tohidi Mohammad, Sabouri Amin, Ramezani-Binabaj Mahdi, Sadeghi-Ghahrodi Mohsen, Einollahi Behzad
机构信息
Researcher, Student Research Committee AND Atherosclerosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Assistant Professor, Atherosclerosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
出版信息
ARYA Atheroscler. 2016 Jan;12(1):41-9.
BACKGROUND
Atherosclerotic event is one of the most causes of death in the world. Coronary artery disease (CAD) is one manifestation of atherosclerosis. It is well-known that several risk factors, such as diabetes mellitus (DM), smoking, hypertension (HTN), have effects on it. It is proposed that infection can lead to atherosclerosis or even make its process faster. Here, we discuss about the effect of some of infectious agents on the atherosclerosis and CAD.
METHODS
In this study, first we did a comprehensive search in PubMed, Scopus, and Science Direct using some related keywords such as atherosclerosis, CAD, myocardial infarction (MI), infection, and name of viruses and bacteria. After finding the related papers, we reviewed the correlation between some microbial agents and risk of CAD.
RESULTS
Literature has reported several infectious agents (viruses, bacteria, and parasites) that can be associated with risk of CAD. This association for some of them like Helicobacter pylori (H. pylori), Chlamydia pneumonia (C. pneumoniae), and Cytomegalovirus (CMV) is a very strong. On the other hand, there are some other agents like influenza that still need to be more investigated through original studies. Furthermore, different mechanisms (general and special) have been reported for the association of each agent with CAD.
CONCLUSION
Based on the studies in databases and our literature review, it is so clear that some microbes and infectious agents can be involved in the process of atherosclerosis. Therefore, controlling each type of infections especially among people with a traditional risk factor for atherosclerosis should be taken into account for reducing the risk of CAD and atherosclerosis.
背景
动脉粥样硬化事件是全球主要死因之一。冠状动脉疾病（CAD）是动脉粥样硬化的一种表现形式。众所周知，糖尿病（DM）、吸烟、高血压（HTN）等多种危险因素会对其产生影响。有人提出，感染可导致动脉粥样硬化，甚至使其进程加快。在此，我们探讨一些感染因子对动脉粥样硬化和CAD的影响。
方法
在本研究中，我们首先在PubMed、Scopus和Science Direct数据库中使用动脉粥样硬化、CAD、心肌梗死（MI）、感染以及病毒和细菌名称等相关关键词进行全面检索。找到相关论文后，我们回顾了一些微生物因子与CAD风险之间的相关性。
结果
文献报道了几种可与CAD风险相关的感染因子（病毒、细菌和寄生虫）。其中一些如幽门螺杆菌（H. pylori）、肺炎衣原体（C. pneumoniae）和巨细胞病毒（CMV）的这种关联非常强烈。另一方面，像流感等其他一些因子仍需要通过原始研究进行更多调查。此外，每种因子与CAD关联的不同机制（一般机制和特殊机制）也有报道。
结论
基于数据库研究和我们的文献综述，很明显一些微生物和感染因子可参与动脉粥样硬化进程。因此，为降低CAD和动脉粥样硬化风险，应考虑控制各类感染，尤其是在有动脉粥样硬化传统危险因素的人群中。
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