Sari Dina Keumala, Ibrahim Nurhadi, Herlina Nina, Arrasyid Nurfida Khairina, Dharmajaya Ridha, Rachmawati Meike, Muhammad Noorzaid, Salazar-Chang Ivan
Nutrition Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatra, Indonesia.
Physiology and Biophysics Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Center Java, Indonesia.
J Exp Pharmacol. 2024 Sep 7;16:271-284. doi: 10.2147/JEP.S466494. eCollection 2024.
Local wisdom food ingredients in North Sumatra, Indonesia, are a source of phenolics which have antioxidant, antihyperlipidemia, neuronal survival, and growth. Administering products with antioxidant properties can provide a supporting effect in preventing inflammation and neurodegenerative process.
The main objective of this study was to analyze the formulation of red palm oil ( Jacq), koja bay leaves ( L Spreng), and passion fruit seeds ( Sims) to improve lipid profile, antioxidant activity, Brain-Derived Neurotrophic Factor (BDNF), and lipase enzyme activity of Sprague-Dawley rats.
This study was an in vivo and pre-post experimental study, starting with analyzing flavonoid of the three extract ingredients, then tested by giving it to rats for 14 days and ending with induction administration of lipopolysaccharide (LPS) for two days. This pre-post study on animals involved 36 rats divided into 6 groups. At the end of the study, termination and examination of malondialdehyde, lipid profile, glucose, BDNF, lipase enzyme activity and histopathological examination were carried out.
The study results showed that there were significant values in several parameters, which were body weight, LDL, LDL/HDL ratio, BDNF, and lipase enzyme activity especially in the group of rats given LPS and the group with high calories-fat-protein. This study showed that there were significant differences in body weight, LDL levels, and LDL/HDL ratio in each group of rats, especially in the group given the formulation of the three extract ingredients, the significant dose showed in 300mg/kg body weight ( < 0.001).
The formulation of red palm oil, koja bay leaves, and passion fruit seeds showed significant reduction in LDL levels, LDL/HDL ratio, BDNF, and lipase enzyme activity.
印度尼西亚北苏门答腊的地方传统食用原料是酚类物质的来源，这些酚类物质具有抗氧化、抗高血脂、促进神经元存活和生长的作用。给予具有抗氧化特性的产品可为预防炎症和神经退行性过程提供支持作用。
本研究的主要目的是分析红棕榈油（雅克）、科贾月桂叶（L·斯普伦格）和西番莲种子（西姆斯）的配方，以改善斯普拉格-道利大鼠的血脂谱、抗氧化活性、脑源性神经营养因子（BDNF）和脂肪酶活性。
本研究是一项体内前后实验研究，首先分析三种提取物成分的黄酮类化合物，然后将其给予大鼠14天进行测试，最后进行为期两天的脂多糖（LPS）诱导给药。这项动物前后研究涉及36只大鼠，分为6组。在研究结束时，进行丙二醛、血脂谱、葡萄糖、BDNF、脂肪酶活性的测定和组织病理学检查。
研究结果显示，在几个参数上有显著值，包括体重、低密度脂蛋白、低密度脂蛋白/高密度脂蛋白比值、BDNF和脂肪酶活性，特别是在给予LPS的大鼠组和高热量脂肪蛋白质组中。本研究表明，每组大鼠的体重、低密度脂蛋白水平和低密度脂蛋白/高密度脂蛋白比值存在显著差异，特别是在给予三种提取物成分配方的组中，显著剂量为300mg/kg体重（<0.001）。
红棕榈油、科贾月桂叶和西番莲种子的配方显示出低密度脂蛋白水平、低密度脂蛋白/高密度脂蛋白比值、BDNF和脂肪酶活性显著降低。
