扫描持续时间对诊断性超声诱导的肺毛细血管出血的影响。
Influence of Scan Duration on Pulmonary Capillary Hemorrhage Induced by Diagnostic Ultrasound.
作者信息
Miller Douglas L, Dong Zhihong, Dou Chunyan, Raghavendran Krishnan
机构信息
Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
出版信息
Ultrasound Med Biol. 2016 Aug;42(8):1942-50. doi: 10.1016/j.ultrasmedbio.2016.03.012. Epub 2016 Apr 23.
Diagnostic ultrasound can induce pulmonary capillary hemorrhage (PCH) in rats and display this as "comet tail" artifacts (CTAs) after a time delay. To test the hypothesis that no PCH occurs for brief scans, anesthetized rats were scanned using a 6-MHz linear array for different durations. PCH was characterized by ultrasound CTAs, micro-computed tomography (μCT), and measurements of fixed lung tissue. The μCT images revealed regions of PCH, sometimes penetrating the entire depth of a lobe, which were reflected in the fixed tissue measurements. At -3 dB of power, PCH was substantial for 300-s scans, but not significant for 25-s scans. At 0 dB, PCH was not strongly dependent on scan durations of 300 to 10 s. Contrary to the hypothesis, CTAs were not evident during most 10-s scans (p > 0.05), but PCH was significant (p = 0.02), indicating that PCH could occur without evidence of the injury in the images.
诊断性超声可诱发大鼠肺毛细血管出血（PCH），并在一段时间延迟后将其显示为“彗尾”伪像（CTA）。为了验证短时间扫描不会发生PCH这一假设，使用6兆赫线性阵列对麻醉大鼠进行不同时长的扫描。通过超声CTA、微型计算机断层扫描（μCT）以及对固定肺组织的测量来表征PCH。μCT图像显示出PCH区域，有时会穿透整个肺叶深度，这在固定组织测量中得到反映。在功率为-3分贝时，300秒扫描的PCH很明显，但25秒扫描时不明显。在0分贝时，PCH对300至10秒的扫描时长没有强烈依赖性。与该假设相反，在大多数10秒扫描期间CTA不明显（p>0.05），但PCH很明显（p=0.02），这表明PCH可能发生而图像中没有损伤迹象。
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