Yu Bo, Xu De-Jun, Sun Huan, Yang Kun, Luo Min
Department of Cardiology, China-Japan Union Hospital, Jilin University;
Department of Basic Foundation, Aviation University of Air Force, Changchun 130022, China.
Acta Cardiol Sin. 2015 Sep;31(5):429-35. doi: 10.6515/acs20150119e.
The aim of this study was to compare and analyze the tensile mechanical properties of the ascending aorta (AA) in Wistar Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs), for the purpose of providing a biomechanical basis for hypertension prevention.
Pulse wave velocities (PWV) and serum nitric oxide (NO) concentrations were determined in 6-month-old WKY rats and SHRs (n = 21, n = 21, respectively). Then, 20 AAs from each group were obtained for longitudinal tensile testing.
The maximum stress, maximum strain, and strain at a tensile stress of 16 Kpa were greater in WKY rats than in SHRs (p < 0.05). The aortic elastic modulus and PWV value were greater in SHRs than in WKY rats (p < 0.05 for both), while NO concentrations were lower in the SHR group than in the WKY group (p < 0.05).
The AA tensile mechanical properties differed between the WKY rats and SHRs, and the tensile mechanical properties of the SHR model had changed.
Ascending aorta; Hypertension; Mechanical properties; Pulse wave velocity; SHR rats; WKY rats.
本研究旨在比较和分析Wistar Kyoto（WKY）大鼠和自发性高血压大鼠（SHR）升主动脉（AA）的拉伸力学性能，为高血压预防提供生物力学依据。
测定6月龄WKY大鼠和SHR（每组各21只）的脉搏波速度（PWV）和血清一氧化氮（NO）浓度。然后，从每组获取20个升主动脉进行纵向拉伸试验。
WKY大鼠的最大应力、最大应变和16 Kpa拉伸应力下的应变均高于SHR（p < 0.05）。SHR的主动脉弹性模量和PWV值高于WKY大鼠（两者均p < 0.05），而SHR组的NO浓度低于WKY组（p < 0.05）。
WKY大鼠和SHR的升主动脉拉伸力学性能不同，SHR模型的拉伸力学性能发生了变化。
升主动脉；高血压；力学性能；脉搏波速度；SHR大鼠；WKY大鼠。
