Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun 130031, Jilin Province, China.
Department of Ophthalmology, Second Hospital, Jilin University, Changchun 130041, Jilin Province, China.
Neural Regen Res. 2012 Oct 15;7(29):2299-304. doi: 10.3969/j.issn.1673-5374.2012.29.009.
The magnitude of tensile stress and tensile strain at an anastomosis site under physiological stress is an important factor for the success of anastomosis following suturing in peripheral nerve injury treatment. Sciatic nerves from fresh adult cadavers were used to create models of sciatic nerve injury. The denervated specimens underwent epineurial and perineurial suturing. The elastic modulus (40.96 ± 2.59 MPa) and Poisson ratio (0.37 ± 0.02) of the normal sciatic nerve were measured by strain electrical measurement. A resistance strain gauge was pasted on the front, back, left, and right of the edge of the anastomosis site after suturing. Strain electrical measurement results showed that the stress and strain values of the sciatic nerve following perineurial suturing were lower than those following epineurial suturing. Scanning electron microscopy revealed that the sciatic nerve fibers were disordered following epineurial compared with perineurial suturing. These results indicate that the effect of perineurial suturing in sciatic nerve injury repair is better than that of epineurial suturing.
在生理应激下吻合部位的拉伸应力和拉伸应变幅度是周围神经损伤治疗中缝合后吻合成功的一个重要因素。本研究使用新鲜成人尸体的坐骨神经来建立坐骨神经损伤模型。去神经标本进行神经外膜和神经束膜缝合。通过应变电测量测量正常坐骨神经的弹性模量（40.96±2.59MPa）和泊松比（0.37±0.02）。缝合后，在吻合部位边缘的前、后、左、右粘贴电阻应变计。应变电测量结果表明，神经束膜缝合后的坐骨神经的应力和应变值低于神经外膜缝合后的坐骨神经。扫描电子显微镜显示，与神经外膜缝合相比，神经束膜缝合后的坐骨神经纤维紊乱。这些结果表明，在坐骨神经损伤修复中，神经束膜缝合的效果优于神经外膜缝合。
