基质辅助激光解吸电离质谱在天然产物分析中的应用。
Application of MALDI Mass Spectrometry in Natural Products Analysis.
作者信息
Silva Ricardo, Lopes Norberto Peporine, Silva Denise Brentan
机构信息
Núcleo de Pesquisa em Produtos Naturais e Sintéticos (NPPNS), Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
出版信息
Planta Med. 2016 May;82(8):671-89. doi: 10.1055/s-0042-104800. Epub 2016 Apr 28.
This article presents the utility of mass spectrometry with a MALDI ionization source in natural products analysis. The advantages and drawbacks of this technique for natural products analyses will be presented and discussed. In addition, the structural determination of secondary metabolites using MALDI-MS/MS will be explored, which can guide MALDI experimental methods and stimulate new research in this area. Finally, several important approaches for MALDI data processing will be discussed.
本文介绍了具有基质辅助激光解吸电离（MALDI）源的质谱在天然产物分析中的应用。将阐述该技术用于天然产物分析的优缺点并进行讨论。此外，还将探讨使用MALDI-MS/MS对次生代谢产物进行结构测定，这可为MALDI实验方法提供指导并推动该领域的新研究。最后，将讨论几种重要的MALDI数据处理方法。
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