通过钯催化2-碘代芳酸与炔酰胺的环化反应区域选择性合成3,4-二取代异香豆素。
Regioselective synthesis of 3,4-disubstituted isocoumarins through the Pd-catalyzed annulation of 2-iodoaromatic acids with ynamides.
作者信息
Liu Hongxu, Yang Yanyan, Wu Jie, Wang Xiao-Na, Chang Junbiao
机构信息
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan 450001, P. R. China.
出版信息
Chem Commun (Camb). 2016 May 21;52(41):6801-4. doi: 10.1039/c6cc01565d. Epub 2016 Apr 28.
PMID:27124602
Abstract
A Pd(0)-catalyzed annulation reaction of ynamides is described for the efficient synthesis of 3,4-disubstituted isocoumarins. This novel methodology allows for the concomitant construction of O-C and C-C bonds between 2-iodoaromatic acids and ynamides, exhibiting excellent regioselectivities and a wide functional group tolerance.
摘要
描述了一种用于高效合成3,4-二取代异香豆素的钯(0)催化的炔酰胺环化反应。这种新方法能够在2-碘代芳酸和炔酰胺之间同时构建O-C键和C-C键，具有出色的区域选择性和广泛的官能团耐受性。
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