Kumar Navaneet, Ansari Mohd Yeshab, Kant Ruchir, Kumar Atul
Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India.
Chem Commun (Camb). 2018 Mar 8;54(21):2627-2630. doi: 10.1039/c7cc09934g.
A copper-catalyzed decarboxylative regioselective protocol for the synthesis of 1,5-disubstituted 1,2,3-triazoles through direct annulation of cinnamic acids with aryl azides has been developed. This is the first example of 1,5-disubstituted 1,2,3-triazoles, under aerobic conditions using Cu(ii) as the catalyst, which were generally synthesized using a ruthenium(ii) catalyst. The simplicity and regioselectivity of this methodology, complementing to the classical CuAAC catalyzed the synthesis of 1,4-disubstituted 1,2,3-triazoles.
已开发出一种铜催化的脱羧区域选择性方法，用于通过肉桂酸与芳基叠氮化物的直接环化反应合成1,5-二取代的1,2,3-三唑。这是在有氧条件下使用Cu(ii)作为催化剂合成1,5-二取代的1,2,3-三唑的首个实例，此类化合物通常使用钌(ii)催化剂合成。该方法的简单性和区域选择性，补充了经典的铜催化的叠氮化物-炔烃环加成反应（CuAAC）催化合成1,4-二取代的1,2,3-三唑的方法。
