胚胎血管发育中的ETS转录因子。
ETS transcription factors in embryonic vascular development.
作者信息
Craig Michael P, Sumanas Saulius
机构信息
Department of Biochemistry and Molecular Biology, Wright State University, 3640 Colonel Glenn Hwy., Dayton, OH, 45435, USA.
Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
出版信息
Angiogenesis. 2016 Jul;19(3):275-85. doi: 10.1007/s10456-016-9511-z. Epub 2016 Apr 28.
Abstract
At least thirteen ETS-domain transcription factors are expressed during embryonic hematopoietic or vascular development and potentially function in the formation and maintenance of the embryonic vasculature or blood lineages. This review summarizes our current understanding of the specific roles played by ETS factors in vasculogenesis and angiogenesis and the implications of functional redundancies between them.
摘要
至少有13种ETS结构域转录因子在胚胎造血或血管发育过程中表达，并可能在胚胎血管系统或血液谱系的形成和维持中发挥作用。本综述总结了我们目前对ETS因子在血管生成和血管新生中所起的特定作用以及它们之间功能冗余的影响的理解。
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