Vohhodina Jekaterina, Harkin D Paul, Savage Kienan I
Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, UK.
Wiley Interdiscip Rev RNA. 2016 Sep;7(5):604-19. doi: 10.1002/wrna.1353. Epub 2016 Apr 28.
Despite consistent research into the molecular principles of the DNA damage repair pathway for almost two decades, it has only recently been found that RNA metabolism is very tightly related to this pathway, and the two ancient biochemical mechanisms act in alliance to maintain cellular genomic integrity. The close links between these pathways are well exemplified by examining the base excision repair pathway, which is now well known for dual roles of many of its members in DNA repair and RNA surveillance, including APE1, SMUG1, and PARP1. With additional links between these pathways steadily emerging, this review aims to provide a summary of the emerging roles for DNA repair proteins in the post-transcriptional regulation of RNAs. WIREs RNA 2016, 7:604-619. doi: 10.1002/wrna.1353 For further resources related to this article, please visit the WIREs website.
尽管近二十年来一直在对DNA损伤修复途径的分子原理进行持续研究，但直到最近才发现RNA代谢与该途径密切相关，这两种古老的生化机制协同作用以维持细胞基因组的完整性。通过研究碱基切除修复途径可以很好地例证这些途径之间的紧密联系，现在已知该途径的许多成员在DNA修复和RNA监测中具有双重作用，包括APE1、SMUG1和PARP1。随着这些途径之间的其他联系不断涌现，本综述旨在总结DNA修复蛋白在RNA转录后调控中的新作用。WIREs RNA 2016, 7:604 - 619。doi: 10.1002/wrna.1353 有关本文的更多资源，请访问WIREs网站。
