Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands.
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands.
Adv Drug Deliv Rev. 2016 Nov 15;106(Pt A):63-72. doi: 10.1016/j.addr.2016.04.021. Epub 2016 Apr 27.
The field of drug delivery has grown tremendously in the past few decades by developing a wide range of advanced drug delivery systems. An interesting category is cell-based drug delivery, which includes encapsulation of drugs inside cells or attached to the surface and subsequent transportation through the body. Another approach involves genetic engineering of cells to secrete therapeutic molecules in a controlled way. The next-generation systems integrate expertise from synthetic biology to generate therapeutic gene networks for highly advanced sensory and output devices. These developments are very exciting for the drug delivery field and could radically change the way we administer biological medicines to chronically ill patients. This review is covering the use of living cells, either as transport system or production-unit, to deliver therapeutic molecules and bioactive proteins inside the body. It describes a wide range of approaches in cell-based drug delivery and highlights exceptional examples.
在过去的几十年中，通过开发广泛的先进药物输送系统，药物输送领域得到了极大的发展。一个有趣的领域是基于细胞的药物输送，其中包括将药物包裹在细胞内或附着在细胞表面，并随后通过体内运输。另一种方法涉及对细胞进行基因工程改造，以控制方式分泌治疗分子。下一代系统集成了合成生物学的专业知识，为高度先进的感觉和输出设备生成治疗基因网络。这些发展对药物输送领域来说非常令人兴奋，可能会彻底改变我们向慢性疾病患者施用生物药物的方式。这篇综述涵盖了使用活细胞作为运输系统或生产单元，在体内输送治疗分子和生物活性蛋白。它描述了基于细胞的药物输送的广泛方法，并突出了一些杰出的例子。
