Department of Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow, India.
J Neurogastroenterol Motil. 2011 Apr;17(2):185-8. doi: 10.5056/jnm.2011.17.2.185. Epub 2011 Apr 27.
Constipation, a common problem in gastroenterology practice, may result from slow colonic transit. Therapeutic options for slow transit constipations are limited. Excessive methane production by the methanogenic gut flora, which is more often found in patients with constipation, slows colonic transit. Thus, reduction in methane production with antibiotic treatment directed against methanogenic flora of the gut may accelerate colonic transit resulting in improvement in constipation. However, there is not much data to prove this hypothesis. We, therefore, report a patient with slow transit constipation associated with high methane production both in fasting state and after ingestion of glucose, whose constipation improved after treatment with non-absorbable antibiotic, rifaximin, which reduced breath methane values.
便秘是消化科常见的问题，可能是由于结肠传输缓慢引起的。对于慢传输型便秘，治疗方法有限。产甲烷肠道菌群过度产生甲烷，这种情况在便秘患者中更为常见，会导致结肠传输缓慢。因此，针对肠道产甲烷菌群的抗生素治疗减少甲烷生成，可能会加速结肠传输，从而改善便秘。然而，目前并没有太多数据来证明这一假说。因此，我们报告了一例慢传输型便秘患者，其空腹和摄入葡萄糖后甲烷生成均较高，在使用不吸收的抗生素利福昔明治疗后，其便秘得到改善，呼吸甲烷值降低。
