人乳头瘤病毒与头颈部口咽鳞状细胞癌：日益严重的流行病。
Human Papillomavirus and Oropharyngeal Squamous Cell Carcinoma of the Head and Neck: A Growing Epidemic.
作者信息
Bauman Jessica, Wirth Lori
出版信息
Adolesc Med State Art Rev. 2014 Aug;25(2):489-501.
Abstract
Human papillomavirus (HPV) is now considered a major causative agent in oropharyngeal squamous cell carcinoma (OP-SCC). The incidence of HPV+ OP-SCC is increasing dramatically, is higher in men, and is now more common than cervical cancer in the United States. HPV+ OPSCCs usually present as locally advanced, stage IV cancers, requiring intensive treatment with surgery, chemotherapy, and/or radiation that can cause tremendous morbidity. HPV vaccination is predicted to prevent HPV+ OP-SCC because over 90% are caused by vaccine-type HPV. However, current vaccination rates are not yet high enough to be effective at preventing HPV-associated malignancies at a population level.
摘要
人乳头瘤病毒（HPV）现在被认为是口咽鳞状细胞癌（OP-SCC）的主要致病因素。HPV阳性OP-SCC的发病率正在急剧上升，男性发病率更高，在美国现在比宫颈癌更常见。HPV阳性OPSCC通常表现为局部晚期IV期癌症，需要通过手术、化疗和/或放疗进行强化治疗，这些治疗可能会导致巨大的发病率。预计HPV疫苗接种可预防HPV阳性OP-SCC，因为超过90%的病例是由疫苗型HPV引起的。然而，目前的疫苗接种率还不够高，无法在人群层面有效预防HPV相关恶性肿瘤。
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