人乳头瘤病毒对口咽癌生物学及治疗反应的影响：对治疗的启示
Impact of human papillomavirus on oropharyngeal cancer biology and response to therapy: implications for treatment.
作者信息
Bonilla-Velez Juliana, Mroz Edmund A, Hammon Rebecca J, Rocco James W
机构信息
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.
出版信息
Otolaryngol Clin North Am. 2013 Aug;46(4):521-43. doi: 10.1016/j.otc.2013.04.009. Epub 2013 Jun 27.
Abstract
Oropharyngeal squamous cell carcinoma (OPSCC) originating from human papillomavirus infection has emerged as a new entity in head and neck cancer, defining a subset of patients with distinct carcinogenesis, risk factor profiles, and clinical presentation that show markedly improved survival than patients with classic OPSCC. De-escalation of therapy and identification of relevant biomarkers to aid in patient selection are actively being investigated. This review addresses the implications of these findings in clinical care.
摘要
起源于人类乳头瘤病毒感染的口咽鳞状细胞癌（OPSCC）已成为头颈癌中的一种新类型，它定义了一组具有独特致癌机制、风险因素特征及临床表现的患者，这些患者的生存率比经典OPSCC患者有显著提高。目前正在积极研究治疗方案的降级以及识别相关生物标志物以辅助患者选择。本综述阐述了这些研究结果在临床护理中的意义。
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