Acra-Tolari Ricardo, Mejía Dolores, Mirambeaux Marcos, Germán Dihmes Alicia
Otolaryngology-Head and Neck Surgery, General Hospital Plaza de la Salud, Santo Domingo, DOM.
Endocrinology, Diabetes and Metabolism, General Hospital Plaza de la Salud, Santo Domingo, DOM.
Cureus. 2022 May 24;14(5):e25300. doi: 10.7759/cureus.25300. eCollection 2022 May.
Previous publications have suggested a link between decreased bone mineral density (BMD) and audiovestibular symptoms. Being the first study, to our knowledge, in the Caribbean region, we aimed to determine the relationship between hearing impairment, vertigo, and tinnitus with BMD in a Dominican postmenopausal population diagnosed with osteoporosis.
A retrospective, cross-sectional, single-center study was conducted. Patients were enrolled using a previous database of Dominican postmenopausal women from 2008 to 2015, including a total of 101 participants. Patients were questioned for hearing difficulty, tinnitus, and vertigo. Body mass index (BMI), Bone Mineral Density (BMD) using T-scores, FRAX score, serum levels of 25-(OH) vitamin D, corrected calcium, phosphate, albumin, alkaline phosphatase, and smoking history were assessed. Statistical analysis was conducted using Chi-square, Mann-Whitney U test, and Odds Ratio.
Median age was 74 years with an interquartile range (IQR) of 12. Fifty-six patients had osteoporosis and 42 osteopenia. Women with osteoporosis diagnosed using a femoral neck T-score demonstrated a greater level of association as well as higher odds of developing vertigo and hearing difficulty than those diagnosed using a hip T-score.
Special attention to the otologic evaluation of these patients as well as increasing the referral to a specialized consult is suggested. Additional multicenter prospective national studies are needed.
先前的出版物表明骨矿物质密度（BMD）降低与听觉前庭症状之间存在联系。据我们所知，这是加勒比地区的第一项研究，我们旨在确定在诊断为骨质疏松症的多米尼加绝经后人群中听力障碍、眩晕和耳鸣与骨矿物质密度之间的关系。
进行了一项回顾性、横断面、单中心研究。使用2008年至2015年多米尼加绝经后妇女的先前数据库招募患者，共有101名参与者。询问患者听力困难、耳鸣和眩晕情况。评估体重指数（BMI）、使用T值的骨矿物质密度（BMD）、FRAX评分、血清25-（OH）维生素D水平、校正钙、磷酸盐、白蛋白、碱性磷酸酶和吸烟史。使用卡方检验、曼-惠特尼U检验和优势比进行统计分析。
中位年龄为74岁，四分位间距（IQR）为12。56例患者患有骨质疏松症，42例患有骨质减少症。与使用髋部T值诊断的患者相比，使用股骨颈T值诊断为骨质疏松症的女性出现眩晕和听力困难的关联程度更高，且几率也更高。
建议对这些患者进行特别的耳科评估，并增加转诊至专科咨询的比例。还需要进行更多的多中心前瞻性全国性研究。
