胆囊收缩素八肽拮抗大鼠中脑导水管周围灰质的吗啡镇痛作用。
Cholecystokinin-octapeptide antagonizes morphine analgesia in periaqueductal gray of the rat.
作者信息
Li Y, Han J S
机构信息
Department of Physiology, Beijing Medical University, People's Republic of China.
出版信息
Brain Res. 1989 Feb 20;480(1-2):105-10. doi: 10.1016/0006-8993(89)91572-2.
PMID:2713644
Abstract
The analgesic effect of systemic morphine (5 mg/kg, s.c.) was dose-dependently antagonized by CCK-8 administered to the periaqueductal gray (PAG) of the rat. This effect could be reversed by proglumide, a CCK-receptor antagonist. The effect of morphine analgesia was potentiated by proglumide administered to PAG. These results are compatible with the notion that PAG is a strategic site where CCK-8 exerts an antiopioid activity.
摘要
给大鼠中脑导水管周围灰质（PAG）注射胆囊收缩素八肽（CCK - 8），可剂量依赖性地拮抗全身注射吗啡（5毫克/千克，皮下注射）的镇痛作用。这种作用可被CCK受体拮抗剂丙谷胺逆转。向PAG注射丙谷胺可增强吗啡的镇痛作用。这些结果与以下观点相符，即PAG是CCK - 8发挥抗阿片样活性的关键部位。
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