白细胞计数及中性粒细胞与淋巴细胞比值在睾丸癌诊断中的应用：一种简单的继发性血清肿瘤标志物
White blood cell counts and neutrophil to lymphocyte ratio in the diagnosis of testicular cancer: a simple secondary serum tumor marker.
作者信息
Yuksel Ozgur Haki, Verit Ayhan, Sahin Aytac, Urkmez Ahmet, Uruc Fatih
机构信息
Department of Urology, Fatih Sultan Mehmet Research & Training Hospital, Istanbul, Turkey.
出版信息
Int Braz J Urol. 2016 Jan-Feb;42(1):53-9. doi: 10.1590/S1677-5538.IBJU.2014.0593.
PURPOSE
The aim of the study was to investigate white blood cell counts and neutrophil to lymphocyte ratio (NLR) as markers of systemic inflammation in the diagnosis of localized testicular cancer as a malignancy with initially low volume.
MATERIALS AND METHODS
Thirty-six patients with localized testicular cancer with a mean age of 34.22±14.89 years and 36 healthy controls with a mean age of 26.67±2.89 years were enrolled in the study. White blood cell counts and NLR were calculated from complete blood cell counts.
RESULTS
White blood cell counts and NLR were statistically significantly higher in patients with testicular cancer compared with the control group (p<0.0001 for all).
CONCLUSIONS
Both white blood cell counts and NLR can be used as a simple test in the diagnosis of testicular cancer besides the well-known accurate serum tumor markers as AFP (alpha fetoprotein), hCG (human chorionic gonadotropin) and LDH (lactate dehydrogenase).
目的
本研究旨在探讨白细胞计数和中性粒细胞与淋巴细胞比值（NLR）作为全身炎症标志物在诊断早期体积较小的局限性睾丸癌（一种恶性肿瘤）中的作用。
材料与方法
本研究纳入了36例平均年龄为34.22±14.89岁的局限性睾丸癌患者以及36例平均年龄为26.67±2.89岁的健康对照者。通过全血细胞计数计算白细胞计数和NLR。
结果
与对照组相比，睾丸癌患者的白细胞计数和NLR在统计学上显著更高（所有p值均<0.0001）。
结论
除了众所周知的准确血清肿瘤标志物，如甲胎蛋白（AFP）、人绒毛膜促性腺激素（hCG）和乳酸脱氢酶（LDH）外，白细胞计数和NLR均可作为睾丸癌诊断中的一项简单检测指标。
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