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独立式与小关节螺钉及椎弓根螺钉增强外侧椎间关节融合术的比较生物力学分析:体外人体尸体模型

A Comparative Biomechanical Analysis of Stand Alone Versus Facet Screw and Pedicle Screw Augmented Lateral Interbody Arthrodesis: An In Vitro Human Cadaveric Model.

作者信息

Kretzer Ryan M, Molina Camilo, Hu Nianbin, Umekoji Hidemasa, Baaj Ali A, Serhan Hassan, Cunningham Bryan W

机构信息

*Western Neurosurgery Ltd., An Affiliated Partner of the Carondelet Neurological Institute, St. Joseph's Hospital, Tucson, AZ†The Orthopaedic Spinal Research Laboratory, St. Joseph Medical Center, Towson‡Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD§Division of Neurosurgery, The University of Arizona Medical Center, Tucson, AZ∥DePuy Spine, a Johnson & Johnson Company, Raynham, MA.

出版信息

Clin Spine Surg. 2016 Aug;29(7):E336-43. doi: 10.1097/BSD.0b013e3182868ef9.

Abstract

STUDY DESIGN

Cadaveric biomechanical study.

OBJECTIVE

To investigate the kinematic response of a stand-alone lateral lumbar interbody cage compared with supplemental posterior fixation with either facet or pedicle screws after lateral discectomy.

SUMMARY OF BACKGROUND DATA

Lateral interbody fusion is a promising minimally invasive fixation technique for lumbar interbody arthrodesis. The biomechanical stability of stand-alone cage placement compared with supplemental posterior fixation with either facet or bilateral pedicle screws remains unclear.

METHODS

A 6-degree of freedom spine simulator was used to test flexibility in 7 human cadaveric specimens. Flexion-extension, lateral-bending, and axial-rotation were tested in the intact condition, followed by destabilization through a lateral discectomy at L2-L3 and L4-L5. Specimens were then reconstructed at both operative segments in the following sequence: (1) lateral interbody cage placement; (2) either Discovery facet screws or the Viper F2 system using a transfacet-pedicular trajectory randomized to L2-L3 or L4-L5; and (3) removal of facet screw fixation followed by placement of bilateral pedicle screw instrumentation. Acute range of motion (ROM) was quantified and analyzed.

RESULTS

All 4 reconstruction groups, including stand-alone interbody cage placement, bilateral Discovery facet screws, the Viper F2 system, and bilateral pedicle screw-rod stabilization, resulted in a significant decrease in acute ROM in all loading modes tested (P<0.05). There were no significant differences observed between the 4 instrumentation groups (P>0.05). Although not statistically significant, the Viper F2 system resulted in greatest reduction of acute ROM in both flexion-extension and axial rotation versus all other treatments (P>0.05).

CONCLUSIONS

Stand-alone interbody cage placement results in a significant reduction in acute ROM at the operative segment in the absence of posterior supplemental fixation. If added fixation is desired, facet screw placement, including the Viper F2 facet screw system using an integrated compression washer and transfacet-pedicular trajectory, provides similar acute stability to the spinal segment compared with traditional bilateral pedicle screw fixation in the setting of lateral interbody cage deployment.

摘要

研究设计

尸体生物力学研究。

目的

研究单纯外侧腰椎椎间融合器与外侧椎间盘切除术后采用小关节或椎弓根螺钉辅助后路固定相比的运动学反应。

背景资料总结

外侧椎间融合术是一种有前景的用于腰椎椎间融合的微创固定技术。单纯椎间融合器置入与采用小关节或双侧椎弓根螺钉辅助后路固定相比的生物力学稳定性尚不清楚。

方法

使用一个6自由度脊柱模拟器测试7具人类尸体标本的灵活性。在完整状态下测试屈伸、侧屈和轴向旋转,随后通过L2-L3和L4-L5节段的外侧椎间盘切除术使其失稳。然后按以下顺序在两个手术节段进行重建:(1)置入外侧椎间融合器;(2)使用Discovery小关节螺钉或采用经小关节-椎弓根入路的Viper F2系统,随机用于L2-L3或L4-L5节段;(3)去除小关节螺钉固定,随后置入双侧椎弓根螺钉内固定装置。对急性活动范围(ROM)进行量化和分析。

结果

所有4个重建组,包括单纯椎间融合器置入、双侧Discovery小关节螺钉、Viper F2系统和双侧椎弓根螺钉-棒稳定术,在所有测试的加载模式下急性ROM均显著降低(P<0.05)。4个内固定组之间未观察到显著差异(P>0.05)。虽然无统计学意义,但与所有其他治疗相比,Viper F2系统在屈伸和轴向旋转时导致急性ROM降低幅度最大(P>0.05)。

结论

在没有后路辅助固定的情况下,单纯椎间融合器置入可使手术节段的急性ROM显著降低。如果需要额外固定,小关节螺钉置入,包括使用一体式加压垫圈和经小关节-椎弓根入路的Viper F2小关节螺钉系统,与外侧椎间融合器置入时传统的双侧椎弓根螺钉固定相比,可为脊柱节段提供相似的急性稳定性。

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