Rusu Mugurel Constantin, Cretoiu Dragos, Vrapciu Alexandra Diana, Hostiuc Sorin, Dermengiu Dan, Manoiu Vasile Sorin, Cretoiu Sanda Maria, Mirancea Nicolae
Division of Anatomy, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
International Society of Regenerative Medicine and Surgery (ISRMS), Bucharest, Romania.
Cell Biol Toxicol. 2016 Jun;32(3):199-207. doi: 10.1007/s10565-016-9328-y. Epub 2016 May 5.
Telocytes (TCs) are typically defined as cells with telopodes by their ultrastructural features. Their presence was reported in various organs, however little is known about their presence in human trigeminal ganglion. To address this issue, samples of trigeminal ganglia were tested by immunocytochemistry for CD34 and examined by transmission electron microscopy (TEM). We found that TCs are CD34 positive and form networks within the ganglion in close vicinity to microvessels and nerve fibers around the neuronal-glial units (NGUs). TEM examination confirmed the existence of spindle-shaped and bipolar TCs with one or two telopodes measuring between 15 to 53 μm. We propose that TCs are cells with stemness capacity which might contribute in regeneration and repair processes by: modulation of the stem cell activity or by acting as progenitors of other cells present in the normal tissue. In addition, further studies are needed to establish if they might influence the neuronal circuits.
端细胞（TCs）通常根据其超微结构特征被定义为具有端粒的细胞。它们存在于各种器官中，然而人们对其在人类三叉神经节中的存在知之甚少。为了解决这个问题，我们通过免疫细胞化学检测三叉神经节样本中的CD34，并通过透射电子显微镜（TEM）进行检查。我们发现端细胞CD34呈阳性，并在神经节内围绕神经胶质细胞单元（NGUs）周围的微血管和神经纤维形成网络。透射电镜检查证实存在纺锤形和双极端细胞，其具有一或两个长度在15至53μm之间的端粒。我们认为端细胞是具有干性能力的细胞，可能通过以下方式促进再生和修复过程：调节干细胞活性或作为正常组织中其他细胞的祖细胞。此外，还需要进一步研究以确定它们是否可能影响神经回路。
