Callen D F, Hyland V J, Baker E G, Fratini A, Gedeon A K, Mulley J C, Fernandez K E, Breuning M H, Sutherland G R
Cytogenetics Unit, Adelaide Children's Hospital, South Australia.
Genomics. 1989 Apr;4(3):348-54. doi: 10.1016/0888-7543(89)90341-8.
Physical mapping of 13 different breakpoints on the short arm of chromosome 16 using previously mapped probes and the subsequent mapping of additional probes enabled the division of this portion of the chromosome into six different intervals. D16S94 was mapped between HBA and D16S80 and is closer to PKD1 than either HBA or D16S80. A tight linkage group which includes FRA16A, D16S8, and D16S79 was identified. Seven breakpoints, including FRA16A, could not be separated by probe localizations. This study provides the basis for the development of detailed maps of the short arm of chromosome 16.
使用先前定位的探针，对16号染色体短臂上的13个不同断点进行物理定位，并随后对其他探针进行定位，使得该染色体的这一部分被划分为六个不同的区间。D16S94被定位在HBA和D16S80之间，并且比HBA或D16S80更靠近PKD1。鉴定出一个紧密连锁群，其中包括FRA16A、D16S8和D16S79。包括FRA16A在内的七个断点无法通过探针定位分开。本研究为绘制16号染色体短臂的详细图谱奠定了基础。
