Lozzio B B, Machado E A, Lair S A, Lozzio C B
Cancer Treat Rep. 1977 Dec;61(9):1679-84.
A primate (Macaca speciosa) antiserum prepared against the human chronic myelogenous leukemia cell line K-562 suppressed the growth of the human myelosarcomas in nude mice. The ip administration of 0.5 ml of immune serum plus 0.5 ml of guinea pig complement, starting 7 days after sc tumor transplantation, resulted in a fourfold to fivefold decrease in tumor weight at 15 days when compared to nude mice given pre-immune serum plus complement or complement alone. Whereas the other two groups experienced an exponential increase in tumor volume at 7-9 days after tumor transplantation, the immune serum-treated mice remained in a "lag" phase of tumor growth during which the tumor volume neither increased nor decreased substantially. Histopathologic studies revealed various degrees of tumor alterations ranging form focal hydropic cellular degeneration to massive coagulation necrosis. The incorporation of tritiated thymidine into the tumors was also markedly diminished in the mice given immune serum.
一种针对人慢性髓性白血病细胞系K - 562制备的灵长类动物（食蟹猴）抗血清抑制了裸鼠体内人骨髓肉瘤的生长。在皮下肿瘤移植7天后开始腹腔注射0.5毫升免疫血清加0.5毫升豚鼠补体，与给予免疫前血清加补体或仅给予补体的裸鼠相比，15天时肿瘤重量减少了四到五倍。在肿瘤移植后7 - 9天，其他两组肿瘤体积呈指数增长，而经免疫血清处理的小鼠肿瘤生长处于“滞后”阶段，在此期间肿瘤体积基本既不增加也不减少。组织病理学研究显示肿瘤有不同程度的改变，从局灶性水样细胞变性到大片状凝固性坏死。给予免疫血清的小鼠肿瘤中氚标记胸腺嘧啶核苷的掺入也明显减少。
