富血小板血浆疗法治疗雄激素性脱发疗效的Meta分析。
Meta-analysis of efficacy of platelet-rich plasma therapy for androgenetic alopecia.
作者信息
Gupta A K, Carviel J L
机构信息
a Department of Medicine , University of Toronto School of Medicine , Toronto , Ontario , Canada.
b Mediprobe Research Inc , London , Ontario , Canada.
出版信息
J Dermatolog Treat. 2017 Feb;28(1):55-58. doi: 10.1080/09546634.2016.1179712. Epub 2016 May 6.
BACKGROUND
Platelet-rich plasma (PRP) therapy is used as an off-label treatment for androgenetic alopecia (AGA); however, published efficacy evidence is still preliminary.
OBJECTIVE
Conduct a meta-analysis of current trial data to estimate efficacy.
METHODS
Thirteen studies which investigated the use of PRP for treatment of AGA were identified from the literature. A meta-analysis was used to analyze results from four trials (N = 60) where sufficient quantifiable data extraction was possible. All 13 studies were analyzed qualitatively.
RESULTS
When comparing PRP treatment to baseline, the overall standardized mean difference was 0.51 [95% confidence interval (CI): 0.14, 0.88; I=0%] in favour of PRP treatment.
CONCLUSION
Preliminary results suggest that the investigation of PRP for the treatment of AGA is promising. Controlled trials with quantifiable measures of treatment success are now required to confirm these results.
背景
富血小板血浆（PRP）疗法被用作雄激素性脱发（AGA）的一种非标签治疗方法；然而，已发表的疗效证据仍属初步。
目的
对当前试验数据进行荟萃分析以评估疗效。
方法
从文献中确定了13项研究，这些研究调查了PRP用于治疗AGA的情况。采用荟萃分析来分析四项试验（N = 60）的结果，这些试验能够进行充分的可量化数据提取。对所有13项研究进行了定性分析。
结果
将PRP治疗与基线进行比较时，总体标准化平均差为0.51 [95%置信区间（CI）：0.14，0.88；I = 0%]，支持PRP治疗。
结论
初步结果表明，研究PRP治疗AGA很有前景。现在需要进行具有可量化治疗成功指标的对照试验来证实这些结果。
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