Georgescu Simona Roxana, Amuzescu Andreea, Mitran Cristina Iulia, Mitran Madalina Irina, Matei Clara, Constantin Carolina, Tampa Mircea, Neagu Monica
Department of Dermatology, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Department of Dermatology, "Victor Babes" Clinical Hospital for Infectious Diseases, 030303 Bucharest, Romania.
J Pers Med. 2022 Feb 24;12(3):342. doi: 10.3390/jpm12030342.
Platelet-rich plasma (PRP) represents a novel therapy tested and is used more and more frequently in dermatology and cosmetic surgery for a variety of conditions, including androgenic alopecia (AGA), a common condition with a complex pathogenesis involving genetic factors, hormonal status and inflammation. We performed an extensive literature search which retrieved 15 clinical trials concerning the use in AGA of PRP therapy, alone or in combination, in male, female or mixed patient groups. A quantitative statistical meta-analysis of = 17 trial groups proved significant increases in hair density from 141.9 ± 108.2 to 177.5 ± 129.7 hairs/cm (mean ± SD) following PRP ( = 0.0004). To the best of our knowledge, this is the first meta-analysis that proved a statistically significant correlation between the number of PRP treatments per month and the percentage change in hair density ( = 0.5, = 0.03), as well as a negative correlation between the mean age of treatment group and the percentage change in hair density ( = -0.56, = 0.016). Other factors considered for analysis were the PRP preparation method, amount used per treatment, hair diameter, terminal hairs and pull test. We conclude that PRP represents a valuable and effective therapy for AGA in both males and females if patients are rigorously selected.
富血小板血浆（PRP）是一种经过测试的新型疗法，在皮肤科和整容手术中越来越频繁地用于治疗多种病症，包括雄激素性脱发（AGA），这是一种常见病症，其发病机制复杂，涉及遗传因素、激素状态和炎症。我们进行了广泛的文献检索，检索到15项关于PRP疗法单独或联合用于男性、女性或混合患者组治疗AGA的临床试验。对17个试验组进行的定量统计荟萃分析证明，PRP治疗后头发密度从141.9±108.2根/平方厘米显著增加至177.5±129.7根/平方厘米（平均值±标准差）（P = 0.0004）。据我们所知，这是第一项荟萃分析，证明每月PRP治疗次数与头发密度变化百分比之间存在统计学显著相关性（r = 0.5，P = 0.03），以及治疗组平均年龄与头发密度变化百分比之间存在负相关性（r = -0.56，P = 0.016）。分析中考虑的其他因素包括PRP制备方法、每次治疗使用量、头发直径、终毛和拔毛试验。我们得出结论，如果对患者进行严格筛选，PRP对男性和女性的AGA都是一种有价值且有效的疗法。
