Kucukler Ferit Kerim, Gorkem Umit, Simsek Yasin, Kocabas Ramazan, Gulen Sebnem, Guler Serdar
a Department of Endocrinology.
b Department of Obstetrics and Gynecology , Faculty of Medicine, Hitit University , Corum , Turkey.
Gynecol Endocrinol. 2016 Sep;32(9):759-761. doi: 10.1080/09513590.2016.1180679. Epub 2016 May 6.
Gestational diabetes mellitus (GDM) occurs in ∼10-25% of pregnancies. Nesfatin-1, plays a role in carbohydrate metabolism by inhibiting glucagon secretion, besides has a glucose-dependent insulinotropic effect. Explanation of the GDM pathogenesis is important due to preventing gestational complications. We aimed to investigate relationship between GDM and Nesfatin-1.
Seventy-nine pregnant subjects were randomly allocated to either GDM group (GDG, n = 38) or control group (CG, n = 41). For GDM diagnosis, 50 and 100 g oral glucose tolerance test (OGTT) were used. Nesfatin-1, insulin and other parameters were measured for all subjects. The homeostasis model assessment-insulin resistance (HOMA-IR) was calculated.
Nesfatin-1 was found lower and insulin was found higher in GDG than CG. Negative correlation has been founded between Nesfatin-1 with weight, BMI, fasting glucose, serum glucose level at first hour of the 50 g OGTT and HOMA-IR.
In this study, patients with GDM had lower Nesfatin-1 levels than without GDM. Therefore, when the Nesfatin-1 effects on the GDM pathogenesis is clear, it may be contributed to diagnosis and treatment of the GDM.
妊娠期糖尿病（GDM）发生于约10%-25%的妊娠中。Nesfatin-1除具有葡萄糖依赖性促胰岛素分泌作用外，还通过抑制胰高血糖素分泌在碳水化合物代谢中发挥作用。由于预防妊娠并发症，解释GDM的发病机制很重要。我们旨在研究GDM与Nesfatin-1之间的关系。
79名孕妇被随机分为GDM组（GDG，n = 38）或对照组（CG，n = 41）。采用50克和100克口服葡萄糖耐量试验（OGTT）诊断GDM。测量所有受试者的Nesfatin-1、胰岛素及其他参数。计算稳态模型评估-胰岛素抵抗（HOMA-IR）。
发现GDG组的Nesfatin-1水平低于CG组，胰岛素水平高于CG组。Nesfatin-1与体重、BMI、空腹血糖、50克OGTT第1小时血糖水平及HOMA-IR之间呈负相关。
在本研究中，GDM患者的Nesfatin-1水平低于非GDM患者。因此，当Nesfatin-1对GDM发病机制的影响明确时，它可能有助于GDM的诊断和治疗。
