O׳Farrell Brendan
DCN Diagnostics Inc, Carlsbad, CA, USA.
Top Companion Anim Med. 2015 Dec;30(4):139-47. doi: 10.1053/j.tcam.2015.12.003. Epub 2015 Dec 21.
In terms of their ability to provide accurate information there is a traditional continuum in diagnostics that ranges from highly accurate methods requiring infrastructure and a centralized approach to testing to less accurate technologies that can be used in a decentralized or point of care testing strategy and that require little to no supporting infrastructure. Today's lateral flow assays marry the utility of a truly field deployable, simple to use technology with the high performance of many laboratory based assay formats. Advances in recent years have allowed for the extension of performance of lateral flow assays into applications that require high accuracy and sensitivity while still maintaining the advantages of the technology from the perspective of infrastructure requirements and user friendliness. This has allowed for improved application of this technology in decentralized testing environments; veterinary, medical and otherwise. The lateral flow assay, once considered less accurate and less capable than infrastructure-heavy, laboratory based formats, is being viewed more and more as a truly versatile technology, capable of more than adequate performance at all ends of the diagnostic continuum. This article discusses the state of the art in lateral flow technology and outlines the utility of the technology in a variety of field based applications.
就提供准确信息的能力而言，诊断领域存在一种传统的连续体，从需要基础设施和集中检测方法的高度准确的方法，到可用于分散式或即时检测策略且几乎不需要支持基础设施的不太准确的技术。如今的侧向流动检测将真正可现场部署、易于使用的技术的实用性与许多基于实验室的检测形式的高性能相结合。近年来的进展使得侧向流动检测的性能扩展到需要高精度和高灵敏度的应用中，同时从基础设施要求和用户友好性的角度来看，仍保持该技术的优势。这使得该技术在分散式检测环境（兽医、医疗及其他领域）中得到了更好的应用。侧向流动检测曾被认为比依赖大量基础设施的基于实验室的检测形式准确性更低、能力更弱，但现在越来越被视为一种真正通用的技术，在诊断连续体的各个层面都能有足够的性能表现。本文讨论了侧向流动技术的现状，并概述了该技术在各种基于现场的应用中的实用性。
